AJ12--Development/Production - Kidney GEC-Specific AAV Vector

Notice ID:36C24E27Q0009

This is a Sources Sought/Request for Information, not a solicitation, for a brand-name-only requirement to develop and produce a kidney glomerular endothelial cell (GEC)-specific AAV vector for VA preclinical research under a VA ORD Merit-funded project. The contractor must independently engineer, produce, and validate the vector, including inserting targeting peptides into the AAV VP1 capsid at position 588/589, confirming GEC selectivity, and testing binding/internalization, biodistribution, transduction efficiency, and off-target effects in culture and murine models. The requirement is associated with the Harry S Truman Memorial Veterans Hospital in Columbia, MO, and includes quarterly reports, weekly videoconference lab meetings, and biannual face-to-face progress meetings in Finland. Task 1 must be completed within one year of the award start date, with Tasks 2 and 3 completed by the end of the second year. Offerors should have endothelial-specific viral vector engineering experience, proven animal and human cell vector delivery, and facilities/equipment meeting AAALAC and FELASA standards.

Department/Ind.Agency Subtier Office
VETERANS AFFAIRS, DEPARTMENT OF VETERANS AFFAIRS, DEPARTMENT OF RPO EAST (36C24E)
  PSC   AJ12 GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE AND TECHNOLOGY; APPLIED RESEARCH
LOCATION: Department of Veteran Affairs Harry S Truman Memorial Veterans Hospital
Primary Contact
Mae McGarry
814-***-2606

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