The Department of Veterans Affairs is seeking qualified vendors to conduct GLP-compliant toxicity and pharmacokinetic studies in adult rats for an experimental rheumatoid arthritis treatment involving peptide-displaying liposomes with dexamethasone. The required services include single-dose intravenous toxicity testing over 14 days, blood analysis for organ damage markers, and LC-MS/MS quantification of dexamethasone and its metabolite. Performance of services will take place at the vendor’s laboratory, with toxicology tasks requiring GLP compliance. The period of performance is one year, from September 15, 2026, to September 14, 2027. No budget amount is specified.

The Department of Veterans Affairs is seeking a contractor to perform preclinical toxicology and pharmacokinetic (PK) studies for an experimental joint targeted liposomal delivery system for Rheumatoid Arthritis therapy. The work includes GLP-compliant single-dose IV toxicity studies in adult rats, as well as GLP or non-GLP PK studies involving IV dosing, blood collection, and LC-MS/MS analysis. The contractor must also provide a comprehensive final written report covering toxicity, PK data, and analytical findings. Performance will take place at the contractor’s laboratory, with an anticipated period of one year from approximately September 15, 2026, through September 14, 2027. No budget amount or submission timeline is specified in this pre-solicitation notice.