Inactive

This effort is required to accomplish Specific Aims of a VA Merit Award (BLRD) to the Principal Investigator (Zhen Yan, PhD). This system will be used to perform electrophysiological recordings of syn... This effort is required to accomplish Specific Aims of a VA Merit Award (BLRD) to the Principal Investigator (Zhen Yan, PhD). This system will be used to perform electrophysiological recordings of synaptic transmission in brain slices in the Yan lab. The BX51WI electrophysiology fixed stage microscope is a microscope particularly suitable for imaging of single cells in thick tissues during electrophysiology experiments from brightfield to IRDIC fluorescence. The BX51WI was specifically designed to suppress electrical noise generated by the frame during critical recording and viewing. The MP-285 micromanipulator offers the precise control of electrode used in patch-clamp recording system. Without this system, it is impossible to perform brain slice recordings for the measurement of neuronal activity.

Inactive

This effort is required to accomplish Specific Aims of a VA Merit Award (BLRD) to the Principal Investigator (Zhen Yan, PhD). This system will be used to perform electrophysiological recordings of syn... This effort is required to accomplish Specific Aims of a VA Merit Award (BLRD) to the Principal Investigator (Zhen Yan, PhD). This system will be used to perform electrophysiological recordings of synaptic transmission in brain slices in the Yan lab. The BX51WI electrophysiology fixed stage microscope is a microscope particularly suitable for imaging of single cells in thick tissues during electrophysiology experiments from brightfield to IRDIC fluorescence. The BX51WI was specifically designed to suppress electrical noise generated by the frame during critical recording and viewing. The MP-285 micromanipulator offers the precise control of electrode used in patch-clamp recording system. Without this system, it is impossible to perform brain slice recordings for the measurement of neuronal activity. The scope of work is the delivery of a BX51WI microscope system with a mounted and connected MP-285 micromanipulator. This requires the assembly and adjustment of the system. The equipment will be located in Building 20, Rm 231 of the Western New York VA Research Facility. The work will be performed solely in Dr. Yan s laboratory.