This is a Sources Sought Notice for market research to identify qualified Service-Disabled Veteran-Owned and Veteran-Owned Small Businesses capable of providing Reduced Representation Bisulfite Sequencing (RRBS) services for DNA methylation profiling of 269 human post-mortem choroid plexus tissue samples in support of a neurodegenerative disease research program at the VA Bedford Healthcare System. Services include sample handling, bisulfite conversion, library preparation, Illumina paired-end sequencing (approximately 30 million read pairs per sample), and raw data alignment with methylation calling and genome browser track generation, with an anticipated turnaround time of 6–8 weeks. The notice is used to determine whether a set-aside is appropriate under the VA "Rule of Two" per the Veterans First Contracting Program. No budget information is provided, and the location for performance of services is not specified. This is not a solicitation and no contract will result directly from this notice.