The U.S. Department of Health and Human Services requires a new, commercially available Zeiss Lattice SIM5 super-resolution light microscope for its National Cancer Institute's Center for Cancer Research Microscopy Core. The Core serves the imaging needs of numerous NCI researchers, and this specific microscope is needed to meet the high demand for super-resolution fluorescence microscopy to study molecular interactions in live cells. The performance location is the CCR Microscopy Core within the National Institutes of Health.