This is a combined synopsis/solicitation for a firm-fixed-price purchase order to acquire maintenance and support for the Pristima Pre-Clinical Data Management System. The acquisition is being issued on a sole-source basis to Xybion Corporation, with competition restricted based on an approved sole source justification. The requirement is not set aside for small business concerns. The contracting activity is the HHS Office of Mission Acquisition Solutions, acting on behalf of the FDA's National Center for Toxicological Research.