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SAM.gov SOURCES SOUGHT NOTICE Solicitation Number: NIMH22003113 Title: Human Cytokine 48-plex and Mouse Cytokine 23-plex Assay Kits NAICS CODE: 334516 – Analytical Laboratory Instrument Manufacturing ... SAM.gov SOURCES SOUGHT NOTICE Solicitation Number: NIMH22003113 Title: Human Cytokine 48-plex and Mouse Cytokine 23-plex Assay Kits NAICS CODE: 334516 – Analytical Laboratory Instrument Manufacturing Classification Code: 6640 – Laboratory Equipment and Supplies Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: Over the past few years we have pioneered applications of a few cytokines and neurotrophic factors for the study of depression and treatment outcomes with rapid antidepressant agents. We propose to leverage vast cytokine and growth factor data in depression and its treatment and gain knowledge on the mechanisms of action of the NMDA antagonist ketamine related to treatment response. Increasing evidence supports the role of glutamatergic system as a prime target system for developing the next generation of antidepressants, particularly by targeting the N-methyl-D-aspartate (NMDA) receptor complex. The detailed mapping of biochemical pathways affected by ketamine and the pathways that are implicated in its mechanism of action could provide a roadmap for better positioning of this drug and for discovering new classes of therapies for the treatment of depressive episodes in depression and bipolar disorder. Purpose and Objectives: The purpose of this requirement is to purchase four Bio-Plex Pro human cytokine 48-plex assay kits and two Bio-Plex Pro mouse 23-plex assay kits or equal human cytokine 48-plex assay kits and mouse 23-plex assay kits to measure these cytokines in a small volume of 80 clinical PBMC samples and mouse plasma samples by Magpix multiplex reader in order to define biomarkers of response to ketamine or LPS. Salient characteristics include the following: The following product characteristics are required for this requirement: Bio-Plex Pro or equal Human cytokine 48-plex assay kit and Mouse cytokine 23-plex assay kits Bio-Rad Laboratories part number(s): (1)12007283; (2) M60009RDPD or assay kits equal to Bio-Rad Laboratories part number(s): (1)12007283; (2) M60009RDPD Magnetic bead–based for simplified plate processing; Developed to deliver accurate, reproducible measurements in multiple sample matrices Requires as little as 12.5 µl of sample for both multiplex assays Available as all-in-one, space-saving complete kit Includes premixed standards for generation of standard curves over a broad dynamic range for each target. Delivery or Deliverables. The contractor shall deliver within 30 days after receipt of the order. The contractor shall provide inside delivery and installation of the equipment within 30 days after receipt of order. Site location address is NIMH, 10 Center Dr. 10 4A07, Bethesda, MD 20892 Capability statement /information sought. Respondents must provide, as part of their responses, a capability statement that clearly identifies their ability to provide the requirements specified in this notice. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. Please note that NIMH is particularly interested in small business sources. If you are a small business, please state the type of small business (small business; HUBZone; service-disabled, veteran-owned; 8(a); veteran-owned; woman-owned; or small disadvantaged businesses) and your size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirements and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Robin Knightly at e-mail address Robin.Knightly@nih.gov The response must be received on or before Friday, April 29, 2022, at 2:00pm Eastern Time. Disclaimer and Important Notes This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).