Inactive

PRE-SOLICITATION NOTICE OF INTENT NON-COMPETITIVE Notice of Intent: NIMH-20-004314 INTRODUCTION PURSUANT TO FAR Subpart 5.2—Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF ... PRE-SOLICITATION NOTICE OF INTENT NON-COMPETITIVE Notice of Intent: NIMH-20-004314 INTRODUCTION PURSUANT TO FAR Subpart 5.2—Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION. THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Office of Acquisitions, Contracts Management Branch Red, NIMH Section on behalf of the National Institute on Mental Health intends to negotiate and award a contract for Inscopix nVoke 2.0 Integrated Calcium Imaging and Optogenetics System with Inscopix, Inc. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS Code 334516: Analytical Laboratory Instrument Manufactoring with a Size Standard of 1000 Employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses of the Federal acquisition Requlation (FAR) in effect through the Federal Acquisition Circular 2020-08, dated 13 August 2020. STATUTORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source. DESCRIPTION OF REQUIREMENT Project Description Inscopix nVoke 2.0 Integrated Calcium Imaging and Optogenetics System for in Vivo in free ranging Studies with hardware/software for control and data acquisition/processing. General Requirements Current approaches to investigations of brain circuits and systems require detailed analyses of neuronal circuit dynamics at cellular or greater resolution across multiple brain regions. Projects being pursued by multiple member of the UNAM lab utilize optogenetic methods to control and monitor the activity of individual neurons, or two-photon microscopy to image calcium indicators in head-fixed animals. The nVoke Integrated Imaging and Optogenetics System for In Vivo is a cutting-edge technology platform that combines both calcium imaging and optogenetics into a single “all-optical” system. This unique technological advance enables simultaneous visualization and optogenetic manipulation of neural circuit dynamics in the same field of view using a head-attached miniature microscope. The unique capability of the Inscopix nVoke 2.0 system is that it resolves single-cell activity in a large neuronal population, and activates or silences them in awake, freely moving animals. The nVoke system provides an innovative solution for investigation of inter-regional functional connectivity, functional cell type mapping and microcircuit functioning, all in the brain of freely behaving animal. Purchase Description: (1) nVoke 2.0 Integrated Imaging and Optogenetics System for in Vivo, Application Module nVoke, ProView™ Lens Probe, Accelerate Training Module, Inscopix Care (1-year subscription) System Trade in; (2) nVoke; (3) Inscopix; (3) Product #s 1000-004339 quantity 1, 1000-004853 system trade in quantity 1, 1000-004377 quantity 1, 1000-002390 quantity 1, 1000-002215 quantity 1, 1000-002897 quantity 1. Period of Performance One time delivery and installation. Sole Source Justification: The essential characteristics of the nVoke System from Inscopixs that limit the availability to a sole source are this is the only commercially available upgrades to the fully integrated implantable microscope into small rodent’s brain with combined optogenetics capabilities usable in free ranging test animals with complete hardware and software components. Specifically, the nVoke Integrated Imaging and Optogenetics System for In Vivo is a cutting-edge technology platform that combines both calcium imaging and optogenetics into a single “all-optical” system. This unique technological advance enables simultaneous visualization and optogenetic manipulation of neural circuit dynamics in the same field of view using a head-attached miniature microscope. The unique capability of the nVoke 2.0 system is that it resolves single-cell activity in a large neuronal population, and activates or silences them in awake, freely moving animals. CLOSING STATEMENT This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. The respondents must submit clear and convincing evidence that their product is equivalent or superior to the product specified in this notice. The response shall include: the unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered to determine the method of acquisition. The response must also indicate the country of manufacturer. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by 21 August 2020 at 2PM Eastern Time and must reference number NIMH-20-004314. Responses must be submitted electronically to Robin Knightly, Contract Specialist, at Robin.Knightly@nih.gov, and must reference the solicitation number NIMH-20-004314, on your electronic request. FAX requests are not accepted. “All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.”