This is a Small Business Sources Sought notice, not a solicitation, intended to identify qualified small business sources for supporting NCI’s Cancer Therapy Evaluation Program enterprise system (CTEP-ESYS). The scope includes enterprise application operations, modernization, clinical trial and biomedical informatics, system integration, data management and analytics, AI/ML-assisted workflow support, security/compliance, and user/program support. The NAICS code is 541512 with a $34M small business size standard, and the Government anticipates a single award. The anticipated period of performance is July 1, 2027 through June 30, 2032. Interested firms must demonstrate capability across the full range of requirements described.