This is a reissued and actively amended Broad Agency Announcement (BAA) from BARDA DRIVe covering numerous research Areas of Interest (AOIs) in health security and medical countermeasures. The AOIs include topics such as diagnostics, vaccines, therapeutics, and digital health, with their statuses—being added, revised, paused, reopened, or closed—frequently updated through amendments. Prospective bidders must consult the latest amendments and the main announcement for the current status, detailed scope, and specific requirements of each AOI. The performance location and budget information are not specified in this summary description.