This program aims to develop a new chiplet-based architecture to create low-cost, modular wearable or ingestible sensors for the continuous monitoring of biological markers like hormones and cytokines. The work involves developing three key components: ultra-low power "dry" chiplets, "wet" biosensor chiplets for biochemical measurement, and new biocompatible packaging strategies. The goal is to enable early disease detection, safe home recovery, and precision therapy monitoring. A solution summary is required by Wednesday, April 8, 2026 at 5:00 PM ET in order to later submit a proposal. No specific budget or performance location is detailed in this description.

This DRAFT notice describes the Delphi Program's vision to develop low-cost, modular wearable or ingestible sensors for continuous monitoring of biological markers like hormones and cytokines. The program aims to leverage chiplet-based microelectronics to reduce cost and size while improving performance, focusing on three key technical areas: ultra-low power management chiplets, secure data communication chiplets, and new "wet" biosensor chiplets for direct biological interface. A final required component is the development of new biocompatible packaging strategies to protect the electronics in biological environments. The end goal is to create a system that enables early disease detection, safe home recovery monitoring, and precision therapy management.