This DRAFT notice describes the Delphi Program's vision to develop low-cost, modular wearable or ingestible sensors for continuous monitoring of biological markers like hormones and cytokines. The program aims to leverage chiplet-based microelectronics to reduce cost and size while improving performance, focusing on three key technical areas: ultra-low power management chiplets, secure data communication chiplets, and new "wet" biosensor chiplets for direct biological interface. A final required component is the development of new biocompatible packaging strategies to protect the electronics in biological environments. The end goal is to create a system that enables early disease detection, safe home recovery monitoring, and precision therapy management.