This Innovative Solutions Opening (ISO) supports the 1-CURE Program, with the Advanced Research Projects Agency for Health (ARPA-H) anticipating multiple Other Transaction Agreements. Proposers are directed to review the attached ISO document and its appendices, as well as a separate Special Notice for a Proposers’ Day event. All questions submitted will be compiled and answered on a dedicated Frequently Asked Questions page, which potential proposers are encouraged to monitor regularly for updates.