This is an amendment notice for the ARPA-H ADVOCATE program, which aims to develop an AI agent system for autonomous clinical care for cardiovascular disease patients. The notice revises several technical and submission sections, including clarifications on proposal eligibility, specifically that proposers for Technical Area 3 (TA3) cannot submit for TA1 or TA2. A Phase 2 for scalability studies is mentioned with a duration of 15 months. No specific budget, performance location, or non-bid timelines are detailed in this amendment summary.

This amendment makes corrections and clarifications to the ADVOCATE program solicitation, which aims to develop an Agentic AI system for autonomous clinical care of cardiovascular disease patients. It specifies that proposers for Technical Area 3 (TA3) cannot submit proposals for TA1 or TA2 in any capacity and are limited to one TA3 proposal. The amendment also updates requirements for disclosing potential Organizational Conflicts of Interest.

This opportunity seeks to develop an autonomous and semi-autonomous clinical care system for patients with cardiovascular disease. The program is run by the Advanced Research Projects Agency for Health (ARPA-H). Interested parties should review the attached Innovative Solutions Opening for full details and a separate Special Notice for information on a Proposers' Day event.