The Advanced Research Projects Agency for Health (ARPA-H) is soliciting solutions for the CIRCLE Program, which aims to create a Control Point Validation Engine to improve ICU outcomes and reduce costs by addressing immuno-inflammatory dysregulation. A Proposer's Day is scheduled for Wednesday, March 11, 2026. Solution summaries are due by Monday, March 30, 2026, at 1 PM ET, and full proposals are due by Thursday, May 28, 2026, at 1 PM ET. ARPA-H will not reimburse submission costs, and proposers should allow up to one month for certain submission steps. No budget amount or performance location is specified.

This solicitation seeks to create a Control Point Validation Engine to improve ICU outcomes and reduce costs by addressing immuno-inflammatory dysregulation. Multiple Other Transaction Agreements are anticipated. The performance location is not specified, and no budget information is provided. Proposers should note that some parts of the submission process may take from one business day to one month to complete.

The Advanced Research Projects Agency for Health (ARPA-H) is soliciting for its CIRCLE Program, which aims to create a Control Point Validation Engine to improve ICU outcomes by predicting and treating immuno-inflammatory dysregulation. Multiple Other Transaction Agreements are anticipated. The performance location is not specified, and no budget information is provided. Proposers should note that some parts of the submission process may take from one business day to one month to complete, and costs for preparing submissions will not be reimbursed.

The Advanced Research Projects Agency for Health (ARPA-H) is soliciting proposals for its CIRCLE Program, which aims to develop a system to assess, predict, and treat immuno-inflammatory dysregulation in ICU patients to improve outcomes and reduce costs. Multiple Other Transaction Agreements are anticipated. The program requires interested parties to submit solution summaries and full proposals through a specified online portal. Proposers should plan for some parts of the submission process to take from one business day to one month to complete, and costs for preparing submissions will not be reimbursed.