This ISO seeks proposals for projects under the ARPA-H Scalable Solutions mission office, aiming to improve healthcare access and affordability by overcoming challenges in geography, distribution, manufacturing, and data. The performance location is the United States, with a focus on addressing healthcare disparities in communities and remote areas. The description details administrative updates to proposal documents, including revisions to sections on organizational conflicts of interest, research security, intellectual property, human and animal subjects, biosecurity, and cost proposal instructions. Specifically, cost proposal updates include clarified labor rate definitions and an increased unit cost threshold for supporting documentation from $5,000 to $10,000. Solution summaries and proposals must be submitted via the provided ARPA-H web portals.