This ISO seeks solution summaries and proposals for projects within the ARPA-H Health Science Futures mission, which focuses on removing scientific and technological limitations to enable future healthcare through cutting-edge, often disease-agnostic research. Solution summaries and proposals must be submitted via specific online portals, and questions must be submitted through a dedicated link. Amendment 3 is effective immediately, though prior submissions will follow the original solicitation rules. Key updates include revisions to administrative policy, cost proposal instructions, and cost proposal workbooks, such as clarifying labor rate definitions and increasing a unit cost threshold for supporting documentation.