This ISO seeks proposals for projects within the ARPA-H Resilient Systems Office's mission to address systemic healthcare challenges through cutting-edge technologies. The performance location is not specified. The description details administrative updates to proposal documents, including revisions to sections on organizational conflicts of interest, research security, intellectual property, human/animal subjects, biosecurity, and cost proposal instructions. A key update increased the unit cost threshold for providing supporting documentation on materials and equipment from $5,000 to $10,000. Specific submission URLs are provided for solution summaries, questions, and full proposals.