NIH’s Office of the Director, Office of Acquisitions, on behalf of NHLBI’s Laboratory of Advanced Microscopy and Biophotonics (LAMB), seeks a firm-fixed-price purchase order for one brand-name Spectra-Physics (Newport/MKS) InSight® X3 Dual Ultrafast Laser System, restricted to the OEM and its authorized distributors and awarded on a best-value basis. The system must integrate with an existing Thorlabs Veneto inverted multiphoton microscope for fluorescence lifetime imaging microscopy (FLIM) and stimulated Raman scattering (SRS) pump-probe experiments studying chemotherapeutic agents’ effects on cellular metabolism. The acquisition is an unrestricted commercial products/services competition under NAICS 334516, with a 1,000-employee small-business size standard, and is not expected to exceed the simplified acquisition threshold. The solicitation uses streamlined commercial-item procedures and incorporates provisions and clauses current through Federal Acquisition Circular 2026-01, effective March 13, 2026.