The National Institute on Neurological Disorders and Stroke (NINDS) is seeking capability information from qualified sources, especially small businesses, to inform the acquisition strategy for a medicinal chemistry support program, including whether a small business set-aside is possible. The program requires full-service medicinal chemistry services—such as SAR analysis and design, synthesis, in vitro ADMET studies, computational chemistry/CADD, and compound logistics—supporting 1-10 concurrent projects across exploratory, hit-to-lead, and lead optimization phases. Vendors must demonstrate relevant experience, professional personnel, facilities, and the ability to scale staff up or down based on project demand. The government has preliminarily determined this requirement is not commercial in nature, but vendors who disagree are encouraged to provide supporting rationale. No budget amounts or performance location are specified; interested parties should submit a detailed response addressing the outlined capabilities.