This procurement seeks a vendor to provide assay development and laboratory testing services for evaluating ADME properties and in vivo pharmacokinetics of novel drug candidates. The work supports the Section on Medicinal Chemistry at NIAAA in derisking compounds for metabolic and alcohol-associated disease therapeutics. Required services include grouped ADME assays such as Caco-2 permeability, MDCK/R brain penetrance, hERG cardiac toxicity, plasma stability/binding, and pharmacokinetic studies in C57BL6 mice. These assays inform structure-activity relationship optimization and oral bioavailability translational potential. Performance is at NIAAA, with no budget or timeline details specified in the description.