The NIH intends to award a non-competitive, sole-source contract to 10X Genomics for a Chromium X controller upgrade. This system performs single-cell analysis of gene expression, immune receptors, and cell surface proteins, supporting research on neurodegenerative diseases using CSF, blood, and tissue samples. The acquisition will not exceed the simplified acquisition threshold of $350,000. Interested parties may submit capability statements, proposals, or quotations, which will be considered by the agency. This synopsis is not a request for competitive proposals.