The NIH is seeking a firm-fixed-price contract for medicinal chemistry support to synthesize HERV-K protease inhibitors under full and open competition. The acquisition is a commercial combined synopsis/solicitation, with a total value not expected to exceed $350,000. Offerors must submit pricing, delivery timeframe, and product/service details, and must be registered in SAM. Evaluation will consider technical capability, price, past performance, and delivery schedule. No performance location is specified; delivery terms and F.O.B. point must be included in quotes.