The National Institute of Diabetes and Digestive and Kidney Diseases requires a High-Performance Liquid Chromatography–Mass Spectrometry (HPLC-MS) system to support research on novel antibiotics and antiviral compounds. This system is essential for identifying, characterizing, and confirming the structures of synthetic and natural compounds. The equipment will be used at the Natural Products Chemistry Section of the Laboratory of Bioorganic Chemistry. Continued operation of this analytical system is critical for ongoing research and publication in peer-reviewed journals. No specific budget amounts, performance location beyond the laboratory, or non-bid timelines were provided.