Inactive

The National Institute on Drug Abuse invites you to submit a proposal responding to the requirements of this RFP No. 75N95024R00006 for "Quantification of Drugs of Abuse and Related Substances in Biol... The National Institute on Drug Abuse invites you to submit a proposal responding to the requirements of this RFP No. 75N95024R00006 for "Quantification of Drugs of Abuse and Related Substances in Biological Specimens". This Request for Proposal is prepared in accordance with the Uniform Contract Format prescribed for Government Wide application by the Federal Acquisition Regulation (FAR). The Uniform Contract Format is both a Request for Proposal and a contract award document. The resulting contract will consist of Parts I, II, III of the Uniform Contract Format. We expect to award a cost reimbursement, level of effort type contract. NIDA estimates this requirement will include a one (1) year Base Period and four (4) one (1) year options and Options for increased quantity to extend performance for total potential performance period of five years. Future year funding will be dependent on the previous year's performance and funding availability. The initial performance period will start on or around March 2024. Interested parties should respond with technical and pricing proposals for the entire project. Please include separate pricing for each individual option period and option quantity. Please refer to Section M for mandatory criteria. Additionally, all offerors must be REGISTERED and have an ACTIVE System for Award Management http://www.sam.gov/ (www.sam.gov) account at the time an offer/proposal is submitted to the Government. All offerors registered in the System for Award Management http://www.sam.gov/(www.sam.gov) must be in full compliance with FAR 52.204-13 System for Award Management Maintenance and FAR 52.207-7 System for Award Management to be eligible to submit a proposal. The Government will not accept proposals from offerors who do not meet the SAM requirement. THIS IS SOLICITED UNDER FULL AND OPEN COMPETITION. The NAICS code applicable to this buy is 541715. See Section L.1.c. of this RFP. General Particularly direct your attention to Part IV, which contains instructions, provisions, and evaluation factors for the submission and review of proposals. The balance of Parts I, II, and III contain provisions, clauses, and special requirements which will be made a part of any resultant award. Review these parts as to the effects on performance capability and technical and cost considerations in the development of your proposal. Do not fill in blanks or otherwise complete portions of Parts I, II, and III which otherwise appear to require the insertion of data. The Government will complete those Parts prior to contract award and (if negotiations are conducted) will tailor those items through final negotiations. You must have an authorized organizational official sign your Business Proposal. It must contain a detailed breakdown of costs by year and individual options, for each cost category/element, an explanation of the basis for all costs, and provide documentation to support these costs. We direct special attention to the Breakdown of Proposed Estimated Costs (plus fixed fee) w/Excel Spreadsheet contained in the Business Proposal Cost Information, Attachment 08. Please provide an electronic copy of the spreadsheet in this format. Do not send encrypted files. Use of the above format will hasten review and award. See Section L.2.c. Business Proposal Instructions for additional detail. Please include a completed Form NIH-2043, “Proposal Summary and Data Record” with the Business Proposal. Note that in addition to telephone and fax numbers, you should include the e-mail addresses of both the Principal Investigator and the responsible business representative on the form. Format and content requirements of your Technical Proposal are detailed in Section L.2.b. Technical Proposal. Also, you should complete the “Technical Proposal Cover Sheet” and use it as the cover sheet for each copy of your technical proposal. It is important that you list all professional personnel and organizations named in the proposal who have any role in the proposed work. This includes your staff, subcontractors, collaborating organizations, and consultants. Show organization affiliation(s) for every person named. You may use extra sheets, as needed, following the format shown in the Technical Proposal Cover Sheet. We will use this information to ensure that no conflicts of interest exist with the selected review committee members. The Offeror must submit its Travel Policy, Total Compensation Plan and Annual Report with the initial Business Proposal. If you want to receive an e-mail notice of any amendments to this RFP, you should register on the SAM.gov website. Also, NIDA will post all amendments, or provide an appropriate link, on the SAM.gov website. Offeror Questions and Intent Requests for clarification, additional information, or correction must be made in writing to the Contract Specialist and Contracting Officer. A completed "Proposal Intent Response Sheet." Attachment 02 of the RFP: Please complete this form and return it to this office on or before December 18, 2023. The Completed Proposal Intent Response Sheet and offeror questions, if any, must be submitted on or before 5:00 P.M. Eastern Time on December 18, 2023. The response sheet and offeror questions must be submitted by e-mail to alex.beraud@nih.gov and tracy.cain@nih.gov with the subject line: “Offeror Intent and Questions – 75N95024R00006” Submitting a Proposal Proposals must be submitted via the electronic Contract Proposal Submission (eCPS) website (https://ecps.nih.gov) and no later than 5:00 p.m., Eastern Standard Time (EST) on January 02, 2024. Proposals submitted by facsimile, e-mail, or hard copy will not be accepted. An official authorized to bind your organization must sign the proposal. Offerors are solely responsible for submitting proposals in a timely manner. Please note that creating an account to submit may take up to three (3) business days. Please plan accordingly. Additional instructions on submitting a proposal via eCPS can be found at https://ecps.nih.gov/howtosubmit and in Attachment 1. All notices related to this solicitation will be posted on SAM (https://www.sam.gov). In accordance with FAR 15.306(a)(3) and FAR 52.215-1, the Government intends to evaluate proposals and award a contract without discussions. Therefore, your initial proposal should contain the best terms from cost or price and technical standpoints. The Government does, however, reserve the right to conduct discussions if the Contracting Officer determines them to be necessary. Disclaimers This RFP does not commit the Government to pay the costs for the preparation and submission of a proposal. The Contracting Officer is the only individual who legally can commit the Government to the expenditure of public funds in connection with this acquisition. Following your proposal submission and our review, the Contracting Officer may seek more information. In accordance with FAR 15.306(a)(3) and FAR 52.215-1, we advise you that the Government intends to evaluate proposals and award a contract without discussions (except clarifications). Therefore, your initial proposal should contain the best terms from cost or price and technical standpoints. However, we reserve the right to conduct discussions if the Contracting Officer later decides them to be necessary. Any contract award for this requirement is contingent on the availability of funds (see FAR 52.232-18, Availability of Funds – April 1984). Requests for any information concerning this RFP should be directed to Alexander Beraud, NIDA Office of Acquisitions, Red Branch, who may be reached on (301) 443-6677; collect calls will not be accepted. Discussions with any other individual outside the NIDA Contracts Management Branch should not occur. PLEASE SEE ATTACHED RFP FOR ALL RELEVANT DETAILS Please see attached Amendment 01 to the Request for Proposal which publicly answers questions submitted by interested vendors. Submission due date remains unchanged. PLEASE NOTE: Please use the following link to submit the small business subcontracting plan: https://osdbu.hhs.gov/subcontracting/27674b6c-0eea-4b8f-bec5-d9791e4a1be7 Please also submit a copy of the Small Business Subcontracting Plan with the Business Proposal. The Small Business Subcontracting plan should be submitted in accordance with FAR 52.219-9. Be aware that the total contract value includes the Base Period + all Option Periods + all Option Quantities.

Inactive

A. Objectives: The National Institute on Drug Addiction (NIDA), Division of Therapeutics and Medical Consequences (DTMC), intends to solicit proposals UNDER FULL AND OPEN COMPETITION procedures from q... A. Objectives: The National Institute on Drug Addiction (NIDA), Division of Therapeutics and Medical Consequences (DTMC), intends to solicit proposals UNDER FULL AND OPEN COMPETITION procedures from qualified organizations certified under NAICS Code 541715; to identify and quantify drugs and their metabolites in biological fluids and tissues such as plasma/serum, urine, sweat, saliva, hair, brain and other tissues. The purpose of this contract is to provide the NIDA DTMC with analytical services and facilities to serve as a reference laboratory by which new methodologies currently under development can be assessed and validated. One of NIDA's primary program objectives is to stimulate and support research on drugs of abuse in pharmacokinetics, metabolism, pharmacology and toxicology. It is essential to identify and quantify drugs and their metabolites in biological fluids and tissues such as plasma/serum, urine, sweat, saliva, hair and brain and other tissues. These drugs may include cannabinoids, opiates, amphetamines, l alpha acetyl methadol (LAAM), naltrexone, methadone, cocaine, phencyclidine, anabolic steroids, opioid peptides and peptidomimetics, benzodiazepines and other drugs and their metabolites. The concentrations of such drugs and metabolites usually appear in biological materials at ng/g or ng/ml levels and therefore require the use of state-of-the-art chromatography methods for separation and highly sensitive instrumentations for identification and quantification, such as gas chromatography mass spectrometry (GC MS), liquid chromatography-mass spectrometry (LC-MS), and LC-MS/MS. There are a number of NIDA research investigators, especially those in the area of biology, who may not have access to the state-of-the art analytical instrumentation for quantifying very small quantities of drugs of abuse and their metabolites in biological specimens. Such analytical instruments are very expensive and specialized expertise is required to operate and maintain them. Moreover, the need for this type of analysis arises a few times a year from of our NIDA research researchers. B. General Requirements: Independently, and not as an agent of the Government, the Contractor shall (1) analyze experimental samples for drug concentrations in biological fluids and/or tissues, (2) develop more specific and sensitive methods for existing drugs or compounds and provide analytical validations for such methods, and (3) develop assays for compounds that are not currently available for which specific and sensitive assays are required by the drug abuse research community and perform the work set forth below. The Government COR shall monitor all work under this contract. The Contract activities will support NIDA in the following Task Areas: The Contractor shall quantify variety of drugs of abuse and other chemical substances and/or their metabolites in biological fluids such as plasma, urine, saliva, sweat and various tissues specimens upon NIDA authorization. Specimen for analysis will be provided by research investigators. The Contractor shall routinely research and modify existing methods to improve specificity and sensitivity for analyzing drugs and their metabolites (at least two per year). The Contractor shall develop and validate a new assay for existing and new compounds (at least one compound per year) upon authorization by the NIDA COR. The Contractor shall develop analytical methods that shall provide sensitivity and specificity for pharmacokinetic studies, usually in ng/mL, or ng/g range. For example, for analysis of LSD in urine and serum, sensitivity of 0.10 ng is required. The NIDA COR may substitute analyses of 150 samples with analytical method development for one drug or compound. The Contractor shall provide relevant literature, data search, and information to the NIDA COR as and when needed. The Contractor shall provide an electronic copy of the monthly, half-yearly, and yearly report regularly to the NIDA COR as specified elsewhere in this statement of work. In addition, the Contractor shall provide an electronic copy of the yearly report regularly to the NIDA Contracting Officer. At the end of the contract an electronic copy of the progress report shall be provided to the NIDA COR and Contracting Officer. This is a follow-on procurement to Contract Number 75N95019C00016 titled “Quantification of Drugs of Abuse and Related Substances in Biological Specimens”. NIDA anticipates a cost reimbursement, level of effort type contract will result from this procurement. NIDA also anticipates the need for Options to extend the period of performance and Options for increased quantity. NIDA estimates this requirement will include a one (1) year Base Period and four (4) one (1) year options to extend performance. C. Mandatory Criteria: This acquisition includes special or unique performance or capability requirements. Due to the nature of the compounds which will be evaluated under this contract, it is mandatory that offerors possess a DEA Research Registration. Due to the nature of the compounds which will be evaluated under this contract, it is mandatory that offerors possess prior to award US Department of Justice Drug Enforcement Administration (DEA) Research Registration for Schedules II to V in order to handle substances under the Controlled Substances Act of 1970. In addition, the successful offeror must either possess or demonstrate the ability to obtain prior to award DEA registration for Schedule I controlled substances prior to awarding the contract. D. Additional Information: RFP No. 75N95024R00006 will be available electronically on or about November 14, 2023. Interested vendors will can access the RFP through www.SAM.gov or through the NIDA website (URL: https://nida.nih.gov/funding/nida-office-acquisitions-contracting#RFP) . All information required for the submission of a proposal will be contained in or accessible through the RFP package. Responses to the RFP will be due approximately 30 days from the release date. NIDA will consider proposals submitted by any responsible offeror. This advertisement does not commit the Government to award a contract. Based upon market research, the Government is not using the policies contained in Part 12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. However, interested persons may identify to the Contracting Officer their interest and capability to satisfy the Government's requirement with a commercial item within 15 days of this notice. PLEASE SEE ATTACHED PRE-SOLICITATION SYNOPSIS FOR ALL RELEVANT DETAILS.