Inactive

The purpose of this amendment is to update the required quantity of a component of the Ultima Investigator Plus Laser Scanning Microscope or equal. Please see details below and in the amendment attach... The purpose of this amendment is to update the required quantity of a component of the Ultima Investigator Plus Laser Scanning Microscope or equal. Please see details below and in the amendment attachments. CSS 75N95023Q00511 Amendment 1 Please see the updated quantity for the item below: HED-HSS – High-Speed Shutter for H10770 PMTs – Qnty – 2 Line Item: 0005 Item: Product Code HED-HSS – High-Speed Shutter for H10770 PMTs Quantity: 2 Total Price: $__________ Line Item: 0005A Item: Equal Product Code ________ – Equipment Name__________ Quantity:2 Total Price: $__________ COMBINED SYNOPSIS / SOLICITATION COMPETITIVE Classification code: 66 Title: Ultima Investigator Plus Laser Scanning Microscope or equal This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is 75N95023Q00511 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures; FAR Subpart 13.5—Simplified Procedures for Certain Commercial Items; and FAR Part 12—Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2023-04, dated 2 June 2023. The solicitation is unrestricted and open to all offerors. The associated NAICS code is 334516 and the small business size standard is 1000 employees. Supplies or Services and Prices The National Institute of Neurological Disorders and Stroke (NINDS) has a requirement for a Bruker Nano Ultima Investigator Plus Laser Scanning Microscope or Equal. The contractor shall deliver and install the required equipment within six (6) months after receipt of order. Delivery must be FOB Destination and must include inside installation. The equipment shall be delivered and installed between the hours of 8:00am and 5:00pm, Bethesda, MD local prevailing time, Monday through Friday. Delivery must be Freight on Board (FOB) Destination and include inside delivery. The equipment shall be delivered and installed in coordination with the NINDS personal [to be named at time of award] at the time the equipment is ready to be shipped. The contractor shall provide an Original Equipment Manufacturer (OEM) certified service technician to perform setup, installation, and training. Price Schedule Line Item: 0001 Item: Product Code INVP-01 – Ultima Investigator Plus Laser Scanning Microscope Quantity: 1 Total Price: $__________ Line Item: 0001A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 0002 Item: Product Code INVP-RG – Resonant Scanner High-Speed Optics Set for InvestigatorPlus Quantity: 1 Total Price: $__________ Line Item: 0002A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 0003 Item: Product Code INVP-MB – Upgrade to Moving X-Y Platform for Investigator Plus Quantity: 1 Total Price: $__________ Line Item: 0003A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 0004 Item: Product Code HED-UP-2 – Upgrade of Both Multi-Alkali PMTs to GaAsP for High-Efficiency Detector Module (0MA and 2 GaAsP Total) Quantity: 1 Total Price: $__________ Line Item: 0004A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 0005 Item: Product Code HED-HSS – High-Speed Shutter for H10770 PMTs Quantity: 2 Total Price: $__________ Line Item: 0005A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 2 Total Price: $__________ Line Item: 0006 Item: Product Code HED-10770-mount – High-Speed Shutter Mount for Hamamatsu 10770 PMT -High-Efficiency Detection Module Quantity: 2 Total Price: $__________ Line Item: 0006A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 0007 Item: Product Code 518708 – High-Speed Shutter Controller Quantity: 1 Total Price: $__________ Line Item: 0007A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 0008 Item: Product Code LI-AOM - Laser Input Optics – Imaging/Uncaging with IntegratedAOM Quantity: 1 Total Price: $__________ Line Item: 0008A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 0009 Item: Product Code 521988 - Objective Dovetail, M25-0.75, mONP Quantity: 1 Total Price: $__________ Line Item: 0009A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 00010 Item: Product Code U-7885 - Beam Expander Lens Set Quantity: 1 Total Price: $__________ Line Item: 00010A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 00011 Item: Product Code INV-Lar - Ultima Investigator Large Rack Upgrade Quantity: 1 Total Price: $__________ Line Item: 00011A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 00012 Item: Product Code 526547 - Plus Platform Sliding Door Light Box / Faraday Cage Quantity: 1 Total Price: $__________ Line Item: 00012A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 00013 Item: Product Code Install-16 - Installation and Training - Single Laser Input Quantity: 1 Total Price: $__________ Line Item: 00013A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Line Item: 00014 Item: Product Code EST-SHIP - Estimated Shipping Quantity: 1 Total Price: $__________ Line Item: 00014A Item: Equal Product Code ________ – Equipment Name__________ Quantity: 1 Total Price: $__________ Total Price: $__________ Background and Requirement The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge. The mission of the NIH also includes enhancing health, lengthening life, reducing illness and disability, conducting, supporting and making medical discoveries that improves and saves people’s health and lives. The National Institute of Neurological Disorders and Stroke (NINDS) Cellular Neurophysiology Section research focuses on circuit and cellular properties of dopaminergic neurons located in the midbrain. We are interested in the physiology of a subset of dopamine neuron located in the substantia nigra pars compacta (SNc) that undergo selective cell death in Parkinson’s patients. Specifically, we are interested in understanding how synaptic and intrinsic conductances (particulary calcium permeable conductances, ie voltage gated calcium channels and glutamate activated receptors) differ among subpopulations dopamine neurons with the hope that this may provide insight to why SNc dopamine neurons are particularly vulnerable in Parkinson’s disease. Our goal is to identify novel physiological and genetic markers in single SNc dopamine neurons which may be useful in defining subpopulations of these neurons in a meaningful way. Because high levels of cytoplasmic Ca2+ has been identified as a possible contributor to the vulnerability of dopamine neurons in Parkinson’s diseases, CNU has been examining Ca2+ handling in the dendrites and spines of dopamine neurons. A two-photon laser microscope enables examination of cytoplasmic calcium in these small subcellular compartments Brand Name or Equal Bruker Nano Ultima Investigator Plus Laser Scanning Microscope INVP-01 – Ultima Investigator Plus Laser Scanning Microscope – Qnty - 1 INVP-RG – Resonant Scanner High-Speed Optics Set for InvestigatorPlus– Qnty - 1 INVP-MB – Upgrade to Moving X-Y Platform for Investigator Plus – Qnty - 1 HED-UP-2 – Upgrade of Both Multi-Alkali PMTs to GaAsP for High-Efficiency Detector Module (0MA and 2 GaAsP Total) – Qnty - 1 HED-HSS – High-Speed Shutter for H10770 PMTs – Qnty - 2 HED-10770-mount - High-Speed Shutter Mount for Hamamatsu 10770 PMT -High-Efficiency Detection Module – Qnty - 2 518708 High-Speed Shutter Controller – Qnty - 1 LI-AOM - Laser Input Optics - Imaging/Uncaging with IntegratedAOM – Qnty - 1 521988 - Objective Dovetail, M25-0.75, mONP – Qnty - 1 U-7885 - Beam Expander Lens Set – Qnty - 1 INV-Lar - Ultima Investigator Large Rack Upgrade – Qnty - 1 526547 - Plus Platform Sliding Door Light Box / Faraday Cage – Qnty - 1 Install-16 - Installation and Training - Single Laser Input – Qnty - 1 EST-SHIP - Estimated Shipping – Qnty - 1 Salient characteristics: The salient physical, functional, or performance characteristics that “equal” products must meet are as follows: The system must employ resonant scanning in the X axis with galvanometer- based scanning in the Y axis. The system must include one GaAsp photomultiplier tubes (PMTs) for sensitive, fluorescence detection of green fluorescence. The system must be useable for in vivo imaging. To do this, we would require a moveable microscope that will be used with a fixed position preparation. The system must include a PC work station, peripherals and software compatible with resonant scanning. The system must be capable of automatically collecting and storing XYZ stacks and must include the option to be controlled by external triggers or deliver a trigger to synchronize with other experimental electronics. The system must have detectors that are in close proximity to the objective and move in unison with the objective. The short and fixed path length between the collection lens and objective will allow for more efficient collection of scattered photons and 14° angle of collection from back aperture of the objective. The system must have 2” Collection optics from the objective to the detectors to ensure that the diverging photons end up hitting the photo cathode of the detectors instead of getting lost along the way. The system must have a rotating nosepiece that swivels 90 degrees on either side of its normal position. This allows users to image regions that are on the back or the side of the head. This feature does not require any re-orientation of the scan head or realignment of laser transfer optics, nor does it affect the optical relationship between the objective and PMT photo cathodes. The system must have a scan head that realizes an optical design optimized for extended scanning field-of-view in galvo mode. The system must maintain a point scan function (PSF) within 1 axial PSF across entire field at scan zoom 1x. Overscan will allow for scan zoom 0.8x for 1.4mm x 1.4mm field of view with Nikon 16x 0.8 objective, which is an overscan field number of 28.3mm. The system should have a motorized Z axis with a standard Z axis 1.25” travel range for automated Z-stacks. The system should allow easy access to animal/specimen for behavioral stimulation. The microscope should be specifically designed for in vivo work that allows plenty of room underneath the objective to accommodate diverse experimental needs. In addition, the design should also allow plenty of room around the scope to bring in behavioral equipment close to the animal without spatial constraints. The software should have excellent synchronization with electrophysiology: The software provides accurate timing information about scans using pixel clock, line clock, and frame clock signals (TTL). These signals can be used to trigger external devices. In addition, the software provides the ability to produce up to 8 analog outputs and record from up to 16 analog inputs synchronized with photo-stimulation experiments. Contract Type and Period of Performance It is the Government’s intent to issue a Firm Fixed Price Purchase Order. The contractor shall deliver and install the required equipment within six (6) months after receipt of order. Delivery must be FOB Destination and must include inside installation. The equipment shall be delivered and installed between the hours of 8:00am and 5:00pm, Bethesda, MD local prevailing time, Monday through Friday. Delivery must be Freight on Board (FOB) Destination and include inside delivery. The equipment shall be delivered and installed in coordination with the NINDS personal [to be named at time of award] at the time the equipment is ready to be shipped. The contractor shall provide an Original Equipment Manufacturer (OEM) certified service technician to perform setup, installation, and training. Place of Performance National Institutes of Health - Main Campus NINDS Cellular Neurophysiology Section 9000 Rockville Pike Bethesda MD 20892 (FOB Destination) Contracting Officer's Representative (COR) The following Contracting Officer's Representative (COR) will represent the Government for the purpose of this contract: [To be specified at time of award] The COR is responsible for: (1) monitoring the Contractor's technical progress, including the surveillance and assessment of performance and recommending to the Contracting Officer changes in requirements; (2) interpreting the statement of work and any other technical performance requirements; (3) performing technical evaluation as required; (4) performing technical inspections and acceptances required by this contract; and (5) assisting in the resolution of technical problems encountered during performance. The Contracting Officer is the only person with authority to act as agent of the Government under this contract. Only the Contracting Officer has authority to: (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; (3) change the delivery schedule; (4) authorize reimbursement to the Contractor for any costs incurred during the performance of this contract; (5) otherwise change any terms and conditions of this contract; or (6) sign written licensing agreements. The Government may unilaterally change its COR designation. The provision at FAR clause 52.212-1, Instructions to Offerors – Commercial Items, applies to this acquisition and is incorporated by reference. The provision at FAR clause 52.212-2, Evaluation – Commercial Items, applies to this acquisition. The Government will award a purchase order resulting from this solicitation on the basis of lowest price technically acceptable. Technical acceptability will be evaluated based upon the following: The Offeror must include all brand name or equal equipment detailed in the project requirements in its quotation. Or Equal equipment must meet or exceed each salient characteristic in the table below. Brand Name or Equal Ultima Investigator Plus Laser Scanning Microscope INVP-01 – Ultima Investigator Plus Laser Scanning Microscope – Qnty - 1 INVP-RG – Resonant Scanner High-Speed Optics Set for InvestigatorPlus– Qnty - 1 INVP-MB – Upgrade to Moving X-Y Platform for Investigator Plus – Qnty - 1 HED-UP-2 – Upgrade of Both Multi-Alkali PMTs to GaAsP for High-Efficiency Detector Module (0MA and 2 GaAsP Total) – Qnty - 1 HED-HSS – High-Speed Shutter for H10770 PMTs – Qnty - 2 HED-10770-mount - High-Speed Shutter Mount for Hamamatsu 10770 PMT -High-Efficiency Detection Module – Qnty - 2 518708 High-Speed Shutter Controller – Qnty - 1 LI-AOM - Laser Input Optics - Imaging/Uncaging with IntegratedAOM – Qnty - 1 521988 - Objective Dovetail, M25-0.75, mONP – Qnty - 1 U-7885 - Beam Expander Lens Set – Qnty - 1 INV-Lar - Ultima Investigator Large Rack Upgrade – Qnty - 1 526547 - Plus Platform Sliding Door Light Box / Faraday Cage – Qnty - 1 Install-16 - Installation and Training - Single Laser Input – Qnty - 1 EST-SHIP - Estimated Shipping – Qnty - 1 Salient characteristics: The salient physical, functional, or performance characteristics that “equal” products must meet are as follows: Yes/No Comment/Reference a) The system must employ resonant scanning in the X axis with galvanometer- b) based scanning in the Y axis. c) The system must include one GaAsp photomultiplier tubes (PMTs) for sensitive, d) fluorescence detection of green fluorescence. e) The system must be useable for in vivo imaging. To do this, we would require a moveable microscope that will be used with a fixed position preparation. f) The system must include a PC work station, peripherals and software compatible with resonant scanning. g) The system must be capable of automatically collecting and storing XYZ stacks and must include the option to be controlled by external triggers or deliver a trigger to synchronize with other experimental electronics. h) The system must have detectors that are in close proximity to the objective and move in unison with the objective. The short and fixed path length between the collection lens and objective will allow for more efficient collection of scattered photons and 14° angle of collection from back aperture of the objective. i) The system must have 2” Collection optics from the objective to the detectors to ensure that the diverging photons end up hitting the photo cathode of the detectors instead of getting lost along the way. j) The system must have a rotating nosepiece that swivels 90 degrees on either side of its normal position. This allows users to image regions that are on the back or the side of the head. This feature does not require any re-orientation of the scan head or realignment of laser transfer optics, nor does it affect the optical relationship between the objective and PMT photo cathodes. k) The system must have a scan head that realizes an optical design optimized for extended scanning field-of-view in galvo mode. The system must maintain a point scan function (PSF) within 1 axial PSF across entire field at scan zoom 1x. Overscan will allow for scan zoom 0.8x for 1.4mm x 1.4mm field of view with Nikon 16x 0.8 objective, which is an overscan field number of 28.3mm. l) The system should have a motorized Z axis with a standard Z axis 1.25” travel range for automated Z-stacks. m) The system should allow easy access to animal/specimen for behavioral stimulation. The microscope should be specifically designed for in vivo work that allows plenty of room underneath the objective to accommodate diverse experimental needs. In addition, the design should also allow plenty of room around the scope to bring in behavioral equipment close to the animal without spatial constraints. n) The software should have excellent synchronization with electrophysiology: The software provides accurate timing information about scans using pixel clock, line clock, and frame clock signals (TTL). These signals can be used to trigger external devices. In addition, the software provides the ability to produce up to 8 analog outputs and record from up to 16 analog inputs synchronized with photo-stimulation experiments. In addition to completing the table above, the respondents must provide brochures and/or published technical specifications that provide evidence of or equal equipments ability to meet the specifications in the table above. Options – Not applicable and will not be evaluated. (c) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. Offerors shall include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications—Commercial Items, with its offer. (see Attachment 2) The FAR clause at 52.212-4, Contract Terms and Conditions – Commercial Items, applies to this acquisition and is incorporated by reference. Addendum to FAR clause 52.212-4, Contract Terms and Conditions—Commercial Items applies to this acquisition. The additional contract terms and conditions are as follows. 52.204-7 System for Award Management (Oct 2018) 52.204-13 System for Award Management Maintenance. (Oct 2018) 52.204-16 Commercial and Government Entity Code Reporting (Aug 2020) 52.204-18 Commercial and Government Entity Code Maintenance (Aug 2020) 52.204-20 Predecessor of Offeror (Aug 2020) 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Nov 2021) 52.242-15 Stop-Work Order (Aug. 1989) (a) The Contracting Officer may, at any time, by written order to the Contractor, require the Contractor to stop all, or any part, of the work called for by this contract for a period of 90 days after the order is delivered to the Contractor, and for any further period to which the parties may agree. The order shall be specifically identified as a stop-work order issued under this clause. Upon receipt of the order, the Contractor shall immediately comply with its terms and take all reasonable steps to minimize the incurrence of costs allocable to the work covered by the order during the period of work stoppage. Within a period of 90 days after a stop-work is delivered to the Contractor, or within any extension of that period to which the parties shall have agreed, the Contracting Officer shall either -- (1) Cancel the stop-work order; or (2) Terminate the work covered by the order as provided in the Default, or the Termination for Convenience of the Government, clause of this contract. (b) If a stop-work order issued under this clause is canceled or the period of the order or any extension thereof expires, the Contractor shall resume work. The Contracting Officer shall make an equitable adjustment in the delivery schedule or contract price, or both, and the contract shall be modified, in writing, accordingly, if -- (1) The stop-work order results in an increase in the time required for, or in the Contractor’s cost properly allocable to, the performance of any part of this contract; and (2) The Contractor asserts its right to the adjustment within 30 days after the end of the period of work stoppage; provided, that, if the Contracting Officer decides the facts justify the action, the Contracting Officer may receive and act upon the claim submitted at any time before final payment under this contract. (c) If a stop-work order is not canceled and the work covered by the order is terminated for the convenience of the Government, the Contracting Officer shall allow reasonable costs resulting from the stop-work order in arriving at the termination settlement. (d) If a stop-work order is not canceled and the work covered by the order is terminated for default, the Contracting Officer shall allow, by equitable adjustment or otherwise, reasonable costs resulting from the stop-work order. (End of Clause) FAR 52.211-6 Brand Name or Equal (Aug 1999) If an item in this solicitation is identified as “brand name or equal,” the purchase description reflects the characteristics and level of quality that will satisfy the Government’s needs. The salient physical, functional, or performance characteristics that “equal” products must meet are specified in the solicitation. (b) To be considered for award, offers of “equal” products, including “equal” products of the brand name manufacturer, must- (1) Meet the salient physical, functional, or performance characteristic specified in this solicitation; (2) Clearly identify the item by- (i) Brand name, if any; and (ii) Make or model number; (3) Include descriptive literature such as illustrations, drawings, or a clear reference to previously furnished descriptive data or information available to the Contracting Officer; and (4) Clearly describe any modifications the offeror plans to make in a product to make it conform to the solicitation requirements. Mark any descriptive material to clearly show the modifications. (c) The Contracting Officer will evaluate “equal” products on the basis of information furnished by the offeror or identified in the offer and reasonably available to the Contracting Officer. The Contracting Officer is not responsible for locating or obtaining any information not identified in the offer. (d) Unless the offeror clearly indicates in its offer that the product being offered is an “equal” product, the offeror shall provide the brand name product referenced in the solicitation. (End of provision) FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders–Commercial Items (Jun 2023), applies to this acquisition and is incorporated by reference. The following clauses listed in FAR clause 52.212-5 that are applicable to the acquisition are: 52.209-6 Protecting the Government’s Interest when Subcontracting with Contractors Debarred, Suspended, or Proposed for Debarment (Nov 2021) 52.204-27 Prohibition on a ByteDance Covered Application (Jun 2023) 52.204-10 Reporting Executive Compensation and First-Tier Subcontract Awards (Jun 2020) 52.222-3 Convict Labor (June 2003) 52.222-19 Child Labor—Cooperation With Authorities and Remedies (Dec 2022) 52.222-21 Prohibition of Segregated Facilities (Apr 2015) 52.222-26 Equal Opportunity (Sep 2016) 52.222-36 Equal Opportunity for Workers With Disabilities (Jun 2020) 52.222-50 Combating Trafficking in Persons (Nov 2021) 52.223-11 Ozone-Depleting Substances and High Global Warming Potential Hydrofluorocarbons (Jun 2016) 52.223-18 Encouraging Contractor Policies to Ban Text Messaging While Driving (Jun 2020) 52.225-1 Buy American – Supplies (Oct 2022) 52.225-13 Restriction on Certain Foreign Purchases (Feb 2021) 52.232-33 Payment by Electronic Funds Transfer-- System for Award Management (Oct. 2018) The following provisions and clauses apply to this acquisition and are attached in full text. Offerors MUST complete the provisions at 52.204-24 and 52.204-26 in accordance with FAR 4.2103 Procedures and submit with its quotation. • FAR 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Nov 2021) (See Attachment 2) • FAR 52.204-26 Covered Telecommunications Equipment or Services-Representation (Oct 2020) (See Attachment 2) • FAR 52.212-5 Contract Terms and Conditions Required To Implement Statutes or Executive Orders—Commercial Products and Commercial Services (JUN 2023) (See Attachment 3) • NIH Invoice and Payment Provisions with IPP (Updated 4/21/2022) (See Attachment 4) There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. The Defense Priorities and Allocations System (DPAS) is not applicable to this requirement. All questions shall be received via email to Sneha Singh at sneha.singh@nih.gov before 10:00 a.m., Eastern Standard Time, on Thursday August 17, 2023. Responses to this solicitation must include clear and convincing evidence of the offeror’s capability of fulfilling the requirement as it relates to the technical evaluation criteria. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.” All responses must be received on or before 10:00 AM, Eastern Standard Time, on Friday, August 25, 2023, and reference RFQ number 75N95023Q00511. Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f). Responses shall be submitted electronically to the Contract Specialist at sneha.singh@nih.gov. Fax responses will not be accepted. For information regarding this solicitation, please contact the Contract Specialist, Sneha Singh at sneha.singh@nih.gov. Attachments: Attachment 1 - Purchase Description Attachment 2 - Additional Terms and Conditions Attachment 3 - FAR 52.212-5 Contract Terms and Conditions – Commercial Products and Commercial Services (JUN 2023) Attachment 4 - NIH Invoicing Instructions with IPP

Inactive

SOURCES SOUGHT NOTICE Solicitation Number: 75N95023Q00511 Title: Two-Photon Scanning Microscope Classification Code: 6640 NAICS Code: 334516 Size Standard: 1,000 Employees Description: This is a Small... SOURCES SOUGHT NOTICE Solicitation Number: 75N95023Q00511 Title: Two-Photon Scanning Microscope Classification Code: 6640 NAICS Code: 334516 Size Standard: 1,000 Employees Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition; and (4) availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement, to determine the method of acquisition, and availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Small businesses are encouraged to respond. For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Background: The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge. The mission of the NIH also includes enhancing health, lengthening life, reducing illness and disability, conducting, supporting and making medical discoveries that improves and saves people’s health and lives. Research in the Cellular Neurophysiology Section focuses on circuit and cellular properties of dopaminergic neurons located in the midbrain. We are interested in the physiology of a subset of dopamine neuron located in the substantia nigra pars compacta (SNc) that undergo selective cell death in Parkinson’s patients. Specifically, we are interested in understanding how synaptic and intrinsic conductances (particulary calcium permeable conductances, ie voltage gated calcium channels and glutamate activated receptors) differ among subpopulations dopamine neurons with the hope that this may provide insight to why SNc dopamine neurons are particularly vulnerable in Parkinson’s disease. Our goal is to identify novel physiological and genetic markers in single SNc dopamine neurons which may be useful in defining subpopulations of these neurons in a meaningful way. Because high levels of cytoplasmic Ca2+ has been identified as a possible contributor to the vulnerability of dopamine neurons in Parkinson’s diseases, CNU has been examining Ca2+ handling in the dendrites and spines of dopamine neurons. A two-photon laser microscope enables examination of cytoplasmic calcium in these small subcellular compartments Purpose and Objectives: The purpose of this requirement is to acquire one (1) two–photon laser scanning microscope system to examine the mechanisms of synaptic integration and dendritic information in dopamine neurons located in the midbrain. Project requirements: The NINDS Cellular Neurophysiology Section requires one (1) two-photon laser scanning microscope system that meets the following requirements: • The system must employ resonant scanning in the X axis with galvanometer- based scanning in the Y axis. • The system must include one GaAsp photomultiplier tubes (PMTs) for sensitive, fluorescence detection of green fluorescence. • The system must be useable for in vivo imaging. To do this, we would require a moveable microscope that will be used with a fixed position preparation. • The system must include a PC work station, peripherals and software compatible with resonant scanning. • The system must be capable of automatically collecting and storing XYZ stacks and must include the option to be controlled by external triggers or deliver a trigger to synchronize with other experimental electronics. The Contractor shall provide an Original Equipment Manufacturer (OEM) certified service technician to perform setup, installation, and training. Warranty - The Contractor shall warrant that the equipment will be free from defects for a period of at least 12 months from the date of installation, inspection by the Government, and acceptance. Anticipated period of performance: The contractor shall deliver and install the required equipment within six (6) months after receipt of order. Delivery must be FOB Destination and must include inside installation. The equipment shall be delivered and installed between the hours of 8:00am and 5:00pm, Bethesda, MD local prevailing time, Monday through Friday. Other important considerations: In case domestic sources are available and capable of fulfilling the Government’s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. Capability statement /information sought. Companies that believe they possess the capabilities to provide the required products or services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The following information shall be included on the first page: 1. Name of Company 2. GSA Contract No. 3. DUNS No./CAGE Code 4. Street Address, City, State, Zip code 5. Name of Person Authorized to Provide Quote 6. Telephone Number and Email Address of Person Authorized to Provide Quote All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Sneha Singh, Contract Specialist at e-mail address Sneha.Singh@nih.gov. The response must be received on or before Tuesday, July 18, 2023, 10:00 AM, Eastern Time. “Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”