Inactive
Notice ID:75N95023Q00416
This is a request to expand our whole body plethysmography system. The system will allow NIDA to study the causes of opioid overdose deaths by comparing the effects of currently approved drugs to trea...
This is a request to expand our whole body plethysmography system. The system will allow NIDA to study the causes of opioid overdose deaths by comparing the effects of currently approved drugs to treat opioid dependence on opioid-induced overdose deaths and studying the potential effects of novel compounds in reversing opioid-induced respiratory depression. The Neurobiology of Additiction Section (NOAS) of the Integrative Neuroscience Research Branch (INRB), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) seeks to to understand how cellular and molecular changes produce changes in particular neurocircuits to convey negative emotional states that contribute to the motivation to seek drugs. The NOAS is examining drug dependence as a complex psychiatric condition characterized by craving, compulsive drug seeking, excessive drug taking, and the emergence of negative emotional states during withdrawal. With the opioid epidemic recently declared a public health emergency due to the unprecedented high levels of opioid-related overdose deaths, NAS is working to test currently approved medications for opioid dependence. There are medications approved for the treatment of opioid addiction. However, it is unknown whether these medications protect or make it worse if an individual relapses to drug taking. In order to examine these effects, a whole-body plethysmography system is required to currently approved medications for opioid dependence as well as novel medications for their potential to block or reverse respiratory depression caused by opioids.
