Inactive

Amendment 1 - Proposal due date extended to 9/5/2023 at 5pm. The purpose of this requirement is to acquire two new brand name or equal Digidata 1550B digitizers and pClamp 11 electrophysiology analysi... Amendment 1 - Proposal due date extended to 9/5/2023 at 5pm. The purpose of this requirement is to acquire two new brand name or equal Digidata 1550B digitizers and pClamp 11 electrophysiology analysis software for electrophysiology and pharmacological experiments at the National Institute of Neurological Disorders and Stroke (NINDS). NINDS’ previous digitizers were damaged in a flood at National Institutes of Health (NIH) Building 35 in December 2022.

Inactive

This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capabil... This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement, to determine the method of acquisition, and availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Small businesses are encouraged to respond. For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Background: The National Institutes of Health (NIH) is an agency of the Department of Health and Human Services and the Federal focal point for health research. Its mission is to seek fundamental knowledge about the nature and behavior of living systems and apply that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Institute of Neurological Disorders and Stroke (NINDS), The Laboratory of Circuits, Synapses, and Molecular Signaling (LCSMS) studies fundamental issues of synaptic transmission, neuronal excitability, neuromodulation, and neural circuit activity using animal models (principally, the mouse). A major line of research employs patch clamp electrophysiology, fluorescence imaging, and optogenetic stimulation in brain slices. For this research, the LCSMS requires two (2) low-noise patch clamp amplifiers, suitable for single channel recording and whole cell patch recording from neurons in brain slices. The amplifiers must also be compatible with extracellular recording.

Inactive

The purpose of this requirement is to acquire, two new 1550B patch clamp amplifiers for electrophysiology and pharmacological experiments. The Digidata 1550B and pClamp 11 software suite are used exte... The purpose of this requirement is to acquire, two new 1550B patch clamp amplifiers for electrophysiology and pharmacological experiments. The Digidata 1550B and pClamp 11 software suite are used extensively by NINDS in many experiments. The software and equipment were damaged in the flood at NIH Building 35 in December 2022.