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The CBBU at NINDS studies microtubules (MTs) and microtubule associated proteins (MAPs) and their interactions. Tubulin is one of the most prevalent proteins in the brain and the polymerized form, mic... The CBBU at NINDS studies microtubules (MTs) and microtubule associated proteins (MAPs) and their interactions. Tubulin is one of the most prevalent proteins in the brain and the polymerized form, microtubules are essential for a wide variety of cellular phenomena. Perturbation to the microtubule cytoskeleton can lead to sever degrative disease. The construction and disassembly of microtubules is a very regulated process in cells. We aim to understand this process at several levels from the molecular to the cellular. In order to do this we employ a wide range of imaging techniques from darkfield, fluoresce and confocal imaging. All of our equipment needs to be driven by current state of the art computers capable of streaming large amounts of data to disk at high speed. We recently suffered a catastrophic flood that necessities the replacement of our instrument computers. NINDS requires three (3) brand name or equal computers workstations in order to study microtubules and microtubule associated proteins. NINDS requires 3 brand name or equal computer and Acquisition Workstations with the following specifications: Dual core Xeon 2.4 Ghz processors 1300 W power supply 128GB RAM 16GB Nvidia Quadro RTX A4000 512 GB M2 SSD drive for OS 8 port NVMe controller 2TB NVMe M2 SSD (8 in a raid array) Raido-0 Configuration for NVMe Controller Warranty and Product Support: At a minimum the Warranty should include: Minimum 1-year manufacturer warranty on all parts and labor included Replacements for shipping damage Replacements for manufacturing defect upon examination Temporary replacement units during warranty period Coverage of shipping cost of temporary replacement unit to the customer Introductory onsite training and support, Technical support by phone and email, Temporary replacement units during repair period Additionally, extended warranty options are available.