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SOURCES SOUGHT NOTICE Solicitation Number: 75N95023Q00219 Title: HEKA EPC 10 USB Patch Clamp Amplifier & Data Acquisition Software or Equal Classification Code: 6640 NAICS Code: 334516 Size Standard: ... SOURCES SOUGHT NOTICE Solicitation Number: 75N95023Q00219 Title: HEKA EPC 10 USB Patch Clamp Amplifier & Data Acquisition Software or Equal Classification Code: 6640 NAICS Code: 334516 Size Standard: 1,000 Employees Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition; and (4) availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement, to determine the method of acquisition, and availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Small businesses are encouraged to respond. For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule). Background: The National Institutes of Health (NIH) is the top federal agency doing and funding medical research in the US, leading to medical advancements that improve people's health and save lives. The objective of the National Institute of Neurological Disorders and Stroke (NINDS) is to find out as much as possible about the brain and nervous system in order to lessen the burden of neurological disease. The synaptic communication between the millions of neurons in our brain is what allows it to work. Understanding the chemical basis of synaptic transmission under normal and abnormal circumstances is our aim. Our research could help in the diagnosis and treatment of prevalent neurological conditions like Alzheimer's disease. We investigate the molecular mechanisms underlying SNARE complex formation and interaction in cultured neurons from the hippocampus and adrenal medulla. An effective amplifier for biological signals is a crucial for our investigation. Without it, the electrophysiological experiment would be impossible for us to do. The fields of synaptic transmission and exocytosis research will both benefit from a quality puller. Purpose and Objectives: The purpose of this requirement is to procure EPC 10 USB Software-controlled Patch Clamp Amplifiers with builtin LIH 8+8 data acquisition interface or equal, which were damaged in a recent flood. Project requirements: The contractor must provide a Patch Clamp Amplifier & Data Acquisition Software as described below: Salient Characteristics HEKA EPC 10 USB Patch Clamp Amplifier or Equal: Patch Clamp Amplifier •Must be able to monitor the changes in the membrane capacitance. •Must be able to monitor the released substances from the vesicles by the amperometry with carbon fiber electrode. •Must be able to apply for single-channel and whole-cell recordings. •Improved noise performance in the important 1-10 kHz band. •Switchable gain during the measurement. •Computer controls the functions of the amplifier; the data acquisition program can access and store variables that describe all of the settings during an experiment. •Computer control must allow the user to highly automated the experiments. •Retrofittable on older EPC 10 amplifiers. Patchmaster Next Software or Equal: Software •Multi-channel stimulation/acquisition software with programmable experiment control and automation. •Digitally compensate the serious resistance of electrode and the capacitance of solution and cell. •Perform as a digital storage oscilloscope. •Perform as a variable analog filter. •Generate a sophisticated pules to measure the changes in membrane capacitance. •Supports HEKA or Equal EPC 10 USB and EPC 800 USB amplifiers and the LIH 8+8 data acquisition interface. •High resolution, low-noise data acquisition interface. Quantity: Three (3) units The Contractor shall provide an Original Equipment Manufacturer (OEM) certified service technician to perform setup and installation. Warranty - The Contractor shall warrant that the equipment will be free from defects for a period of at least 12 months from the date of installation, inspection by the Government, and acceptance. Anticipated period of performance: The contractor shall deliver and install all equipment within 8 weeks after receipt of order (ARO). Delivery must be Freight on Board (FOB) destination, include inside delivery, and be coordinated with the Contracting Officer’s Representative (COR) prior to shipment. Other important considerations: In case domestic sources are available and capable of fulfilling the Government’s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. Capability statement /information sought. Companies that believe they possess the capabilities to provide the required products or services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The following information shall be included on the first page: 1. Name of Company 2. GSA Contract No. 3. DUNS No./CAGE Code 4. Street Address, City, State, Zip code 5. Name of Person Authorized to Provide Quote 6. Telephone Number and Email Address of Person Authorized to Provide Quote All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Sneha Singh, Contract Specialist at e-mail address Sneha.Singh@nih.gov. The response must be received on or before Friday, April 21, 2023, 10:00 AM, Eastern Time. “Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”