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PURCHASE DESCRIPTION Statement of Need and Purpose: Two Technical Manufacturing Corp (TMC) STACIS iX Laser Tables are required by the Cell Biology and Biophysics unit (CBBU) at NINDS to replace two ta... PURCHASE DESCRIPTION Statement of Need and Purpose: Two Technical Manufacturing Corp (TMC) STACIS iX Laser Tables are required by the Cell Biology and Biophysics unit (CBBU) at NINDS to replace two tables that were damaged in a recent flood. The STACIS iX LaserTables offters hybrid (Passive and Active) vibration isolation and offers vibration isolation down to 0.6Hz. This level of isolation is necessary for the CBBU to perform single molecule localization and super resolution experiments. Background Information and Objective: The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the National Institutes of Health (NIH), conducting research into the causes, treatment, and prevention of neurological disorders and stroke. The NINDS mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. The NINDS Cell Biology and Biophysics Unit performs measurements of microtubules and microtubule associated proteins and their kinetics and dynamics at the single molecule level. To discern the molecular level events, we need to perform super resolution and localization microscopy. These experiments necessitate the need to have a stable platform that isolates all vibration from the outside. The Technical Manufacturing Corp STACIs iX Laser tables are the only choice to meet our needs down to 0.6Hz damping. In addition to providing structural support, microtubules form a complex and dynamic intracellular "highway" that delivers molecular cargo from one end of the cell to another - which in the case of neuronal cells can span several feet. Given the continually changing cell physiology, this delivery system undergoes constant remodeling as cargo is transported to different destinations with high temporal and spatial accuracy. Failures in this highly coordinated transport system lead to disease and mutations in genes that encode microtubule dynamics regulators have been implicated in neurodegeneration, cardiovascular disease, cancers and viral infections. These two Laser Tables will eliminate the vibration and distortion normally seen through lasers scopes mounted on tables with less sensitivity so researchers are able to analyze and examine intracellular highways. Generic Name of Product: Laser Table Purchase Description: The vendor shall provide Two Technical Manufacturing Corp STACIS iX Laster Tables with the minimum specification provided in the salient characteristics section below. Trade Name : Laser Tables Brand Name: Technical Manufacturing Corp Manufactures Name : TMC STACIS iX Laser Table Model Type : STACIS iX Laser table 6’x8’ and 4’x6’