Inactive

The NINDS is a part of the National Institutes of Health (NIH) and conducts research into the causes, treatment, and prevention of neurological disorders and stroke. The Lab or Neurogenetics has been ... The NINDS is a part of the National Institutes of Health (NIH) and conducts research into the causes, treatment, and prevention of neurological disorders and stroke. The Lab or Neurogenetics has been testing a hypothesis involving a point mutation in NRG1 gene, believed to be associated with psychosis, by performing bulk RNA-sequencing on micro-dissected regions of mouse brain tissue. The next stage in the investigation is exploring cell-type-specific effects of this mutation on RNA levels as well as chromatin accessibility. RNA sequencing is currently performed on-site using a 10X Genomics Chromium platform. Performing the planned single-cell experiments using this platform requires using the Chromium Next GEM Single Cell Multiome ATAC + Gene Expression Reagent Bundle (16rxns) and associated items. Please see Attachment 1 - Purchase Description for a complete description of the requirement.