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Custom Tecan EVO 150 Liquid Handling Platform- Brand Name or Equal COMBINED SYNOPSIS / SOLICITATION COVID-19 75N95022Q00212 INTRODUCTION This is a combined synopsis/solicitation for commercial items p... Custom Tecan EVO 150 Liquid Handling Platform- Brand Name or Equal COMBINED SYNOPSIS / SOLICITATION COVID-19 75N95022Q00212 INTRODUCTION This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is 75N95022Q00212 and the solicitation is issued as a request for quotation (RFQ). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE This requirement is assigned North American Industry Classification System (NAICS) code 334516 with a size standard of 1,000 employees. SET-ASIDE STATUS This acquisition is full and open with no set aside restrictions. ACQUISITION AUTHORITY This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures; FAR Subpart 13.5— Simplified Procedures for Certain Commercial Items; and FAR Part 12—Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) Number 2022-04, with effective date January 30, 2022. DESCRIPTION OF REQUIREMENT Purpose This requisition is to purchase a customized Tecan Freedom EVO150 liquid handling platform designed for use in the FluidCore automated purification system developed by the Analytical Chemistry Core (ACC) within the Division of Preclinical Innovation (DPI) at NCATS. Project Requirements See Attached Purchase Description for details. Place of Performance The place of performance shall be the National Institutes of Health, National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center, Bldg. B, Rockville, MD 20850. Contract Type The Government intends to issue a firm fixed price purchase order for this requirement. Invoicing shall be in accordance with the Prompt Payment Act and payment shall be made via Electronic Funds Transfer (EFT). Response Format Responses to this solicitation must include clear and convincing evidence of the offeror’s capability of fulfilling the requirement as it relates to the salient characteristics of the product. The offeror must identify in their response where parts/equipment are manufactured. The offeror must indicate in their response as to whether the brand-name or equal product proposed can or cannot meet the salient characteristics as stated in this combined solicitation synopsis. In addition, the quote must provide their company name, Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.” EVALUATION The provision at FAR clause 52.212-2, Evaluation-Commercial Items, applies to this acquisition. (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers: (i) technical capability of the items offered to meet the Government requirement; (ii) past performance, and (iii) price. Technical capability and past performance, when combined, are significantly more important than price. (b) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. Award will be made on all or none basis. If you are providing an "equal" product, you must submit additional documentation that highlights and describes how your offering is equal in accordance with FAR Clause 52.211-6. FAR 52.211-6 BRAND NAME OR EQUAL (AUG 1999) If an item in this solicitation is identified as "brand name or equal," the purchase description reflects the characteristics and level of quality that will satisfy the Government's needs. The salient physical, functional, or performance characteristics that "equal" products must meet are specified in the solicitation. To be considered for award, offers of "equal" products, including "equal" products of the brand name manufacturer, must- Meet the salient physical, functional, or performance characteristic specified in this solicitation; Clearly identify the item by- Brand name, if any; and Make or model number; Include descriptive literature such as illustrations, drawings, or a clear reference to previously furnished descriptive data or information available to the Contracting Officer; and Clearly describe any modification the offeror plans to make in a product to make it conform to the solicitation requirements. Mark any descriptive material to clearly show the modification. The Contracting Officer will evaluate "equal" products based on information furnished by the offeror or identified in the offer and reasonably available to the Contracting Officer. The Contracting Officer is not responsible for locating or obtaining any information not identified in the offer. Unless the offeror clearly indicates in its offer that the product being offered is an "equal" product, the offeror shall provide the brand name product referenced in the solicitation. ADDITIONAL INFORMATION The following provisions apply to this acquisition and are incorporated by reference: • FAR 52.204-7, System for Award Management (Oct 2018) • FAR 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020) • FAR 52.211-6, Brand Name or Equal (Aug 1999) • FAR 52.212-1, Instructions to Offerors-Commercial Items (Nov 2021) • FAR 52.212-3, Offeror Representations and Certifications-Commercial Items (Nov 2021) • FAR 52.225-1, Buy American - Supplies (Nov 2021) • FAR 52.225-3 Buy American-Free Trade Agreements-Israeli Trade Act (Nov 2021), is checked on the 52.212-5 attachment, include: FAR 52.225-4, Buy American-Free Trade Agreements-Israel Trade Act Certificate (Feb 2021) • FAR 52.225-3 Buy American-Free Trade Agreements-Israeli Trade Act with Alternate I, II, or III (Nov 2021) • FAR 52.225-5 Trade Agreements (Oct 2019) • HHSAR 352.239-73, Electronic and Information Technology Accessibility Notice (December 18, 2015) The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998), applies to this acquisition. This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at these addresses:https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html (End of clause) The following clauses apply to this acquisition and are incorporated by reference: • FAR 52.204-13, System for Award Management Maintenance (Oct 2018) • FAR 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020) • FAR 52.212-4, Contract Terms and Conditions--Commercial Items (NOV 2021). Addendum to this FAR clause applies to this acquisition and is included as an attachment. The following provisions and clauses apply to this acquisition and are attached in full text: • FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders--Commercial Items (Jan 2021) • NIH Invoice and Payment Provisions (Feb 2021) (i). The Offerors to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications-Commercial Items (Nov 2021), with its offer. (ii). The clause at FAR 52.212-4, Contract Terms and Conditions-Commercial Items (Nov 2021). Addendum to this FAR clause applies to this acquisition and is attached. (iii). The clause at FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (May 2022), applies to this acquisition and it is attached in full text. (iv). The following additional contract requirement(s) or terms and conditions as determined by the contracting officer are necessary for this acquisition and consistent with customary commercial practices and include contract warranty requirements: (v). The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. (vi). Respondents proposing on an equal product of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order. The Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. Closing Information All questions must be received by 3:00 p.m. Eastern Standard Time, on May 31, 2022, and reference Solicitation Number 75N95022Q00212. Questions may be submitted via electronic mail to michelle.cecilia@nih.gov. All quotations must be received by 3:00p.m., Eastern Standard Time, on June 6, 2022, and reference Solicitation Number 75N95022Q00212. Responses must be submitted via electronic mail to michelle.cecilia@nih.gov. Fax responses will not be accepted. ATTACHMENTS Attachment 1 – Purchase Description Attachment 2 – FAR 52.225-2, Buy American Certificate Attachment 3 – NIH Invoice and Payment Provisions Attachment 4 – FAR 52.212-5, Contract Terms and Conditions – Commercial Items Attachment 5 - FAR 52.214-4, Addendum

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SOURCES SOUGHT NOTICE 1. Solicitation Number: 75N95022Q00212 2. Title: Custom automated purification fraction collection bed 3. Classification Code: 6640 – Instruments and Laboratory Equipment 4. NAIC... SOURCES SOUGHT NOTICE 1. Solicitation Number: 75N95022Q00212 2. Title: Custom automated purification fraction collection bed 3. Classification Code: 6640 – Instruments and Laboratory Equipment 4. NAICS Code: 334516 – Analytical Laboratory Instrument Manufacturing 5. Size Standard: 1,000 6. Description: This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: NCATS has become a key partner in the Antiviral Program for Pandemics (APP), a multi-agency initiative that includes NIAID and BARDA, to accelerate antiviral development through early discovery and preclinical development of safe and effective oral antivirals. The initial priority for the APP is to develop treatments for SARS-CoV-2 and other coronaviruses, with the program expanding to address other virus families with pandemic potential. NCATS will apply its proficiency in drug discovery and development and its cutting-edge technologies to fill critical needs of the APP, such as (i) target validation, (ii) high-throughput screening (HTS) for drug starting points, (iii) medicinal chemistry for lead optimization, and (iv) preclinical, investigational new drug (IND)-enabling development. APP chemists within DPI are tasked with the discovery and development potential small molecule antiviral treatments for a range of viruses that have pandemic potential. In order to meet the increased demand for sample purification and analysis, the Analytical Chemistry Core (ACC) needs to improve throughput and expand capabilities through procurement of additional instrumentation and equipment, as well as the application of new technologies. Purpose and Objectives: The concepts of throughput and cycle time are of great significance to translational scientists as they endeavor to increase experimental capacity while reducing the therapeutic discovery and development timeline in an effort to rapidly bring more treatments to patients. The development of an efficient method for the transfer of compounds from Medicinal Chemistry to Compound Management (CoMa) enables a faster turnaround between small molecule synthesis and biological assays. The compound workflow consists of 5 stages (synthesis, purification, processing, registration, and storage) each comprised of multiple steps. The ACC is responsible for purification, processing, and registration and has created the SMART Centralized Sample Purification and Processing Platform where internally synthesized compounds progress from sample submission to CoMa in only 5 days (2 days for purification, 2 days for processing, and 1 day for registration). The rationale is that by having the ACC conduct the majority of sample purifications the medicinal chemists are afforded more time to focus on synthesizing compounds and thus establishing a streamlined compound synthesis workflow, which is more efficient and productive. Column chromatography is a single-sample-at-a-time process often making purification a major bottleneck in the medicinal chemistry pipeline. Despite this fixed parameter, advancements can be made with instrumentation, automation, methods development, and systems integration to create the most efficient purification workflow possible. The ACC has designed the FluidCore automated purification system as our solution for the technological problem of sample throughput. The ACC worked with Tecan on the design and development of an innovative and custom sample management and fraction collection platform built around the Tecan Freedom EVO150 liquid handling system. This custom Tecan Freedom EVO150 utilizes a dual arm fraction collection bed capable of accommodating a wide range of sample vessels, which can be arranged in a variety of configurations. The FluidCore system consists of the custom Tecan Freedom EVO150 platform connected with Waters analytical and purification LC instrumentation creating a single platform for automated purification. By developing the FluidCore automated purification system, current manual steps of the workflow will be replaced with automated protocols. The integrated Waters analytical UPLC-MS will be used to analyze pre-purification samples for automated method development. The Waters preparative LCMS will then use this method for purification of the sample where individual fractions are dispensed into containers on the custom Tecan Freedom EVO150 fraction collection bed followed by automated fraction analysis by the analytical UPLC-MS. Performance of all these processes within the same platform in an automated fashion will improve operational efficiency and reduce the cycle time for a compound to go from synthesis to plating in an effort to accelerate the drug discovery process. The custom Tecan Freedom EVO150 liquid handling platform is required as it is the core component of the ACC FluidCore automated purification system. Project requirements: Custom Tecan EVO 150 Liquid Handling Platform – Brand name or similar . us10294 - LCMS Purification EWS With the following custom configuration: a. Freedom EVO150 i. 10641150 - Freedom EVO 150 Base Unit, includes 1 year warranty; QTY: 1 ii. 10643121 - Deck, 150, Stainless Steel; QTY: 1 iii. 30097461 - Safety Shield Set, Closed, Freedom EVO 150, Grey; QTY: 1 iv. 10619674 - System Liquid Container, 30L; QTY: 2 v. 10619820 - Waste Liquid Container, 30L, Freedom EVO; QTY: 2 vi. CER - Cutout for waste chute; QTY: 1 b. Arm #1- 8-Channel Liquid Handling Arm i. 10642102 - Liquid Handling Arm (LiHa), 8-tip; QTY: 1 ii. 30019983 - Tubing, Interconnect, required for each Liquid Channel; QTY: 8 iii. 30019982 - Tubing, Pipette, Standard Volume, FEP, 2.5mm x 1.5mm, Length 3.1M; QTY: 8 iv. 10619426 - Syringe, 2500?L, XP diluters, flat cap; QTY: 8 v. 30029016 - FastWash Dual Pump, Upgrade Kit, Standard Tubing, 2 LiHa System; QTY: 1 vi. 10613001 - Wash Station, LiHa, Standard, Freedom EVO; QTY: 1 vii. 10643050 - Tip, Standard, Non-adjustable, PTFE Coated, includes Lock Nut; QTY: 4 viii. 30019984 - Disposable Tip Cone Assembly, Standard; QTY: 4 c. Arm #2- 8-Channel Liquid Handling Arm i. 10642005 - Second Liquid Handling Arm (LiHa), 8-tip; QTY: 1 ii. 30019983 - Tubing, Interconnect, required for each Liquid Channel; QTY: 8 iii. 30019982 - Tubing, Pipette, Standard Volume, FEP, 2.5mm x 1.5mm, Length 3.1M; QTY: 8 iv. 10619426 - Syringe, 2500?L, XP diluters, flat cap; QTY: 8 v. 10613001 - Wash Station, LiHa, Standard, Freedom EVO; QTY: 1 vi. 10643050 - Tip, Standard, Non-adjustable, PTFE Coated, includes Lock Nut; QTY: 4 vii. 30019984 - Disposable Tip Cone Assembly, Standard; QTY: 4 d. Robotic Gripper Arm i. 30013045 - Robotic Manipulator Arm (RoMa), extended z-rail; QTY: 1 ii. 30017037 - RoMa Fingers, Standard Length, set of 2; QTY: 1 iii. CER - Deck Cut Out; QTY: 1 iv. CER - Shelf on deck for tube racks; QTY: 1 e. Diluter, Valve and Tubing for LCMS Loading i. CER - Diluter; QTY: 2 ii. CER - Valve System; QTY: 2 iii. CER - Tubing; QTY: 2 iv. CER - Control Board; QTY: 2 f. Vacuum for Tube Evacuation i. 30119213 - US Valve Isolation 2-Way; QTY: 2 ii. 30045068 - Vacuum Pump, Chemically Resistant, Te-VacS External Vacuum Option; QTY: 2 iii. 30098066 - Silencer for KNF Vacuum Pump; QTY: 2 iv. 30031385 - Bottle Set, Standard, for Vacuum Filtration, HydroFlex; QTY: 1 v. CER - Tubing and Fittings; QTY: 1 g. Robotic Gripper Arm i. 30013045 - Robotic Manipulator Arm (RoMa), extended z-rail; QTY: 1 ii. 30017037 - RoMa Fingers, Standard Length, set of 2; QTY: 1 iii. CER - Deck Cut Out; QTY: 1 iv. CER - Shelf on deck for tube racks; QTY: 1 h. Diluter, Valve and Tubing for LCMS Loading i. CER - Diluter; QTY: 2 ii. CER - Valve System; QTY: 2 iii. CER - Tubing; QTY: 2 iv. CER - Control Board; QTY: 2 i. Six Way Valve and Dispenser for Flasks i. 30079442 - Valve, 6-Way, Large Volume; QTY: 1 ii. 30012177 - Tubing, 6-Way Valve; QTY: 1 iii. CER - Dispenser system for flasks; QTY: 1 j. Computer and Software i. 10615150 - EVOware Standard Software, EVO 100, 150, and 200; QTY: 1 ii. 30158027 - Computer, Desktop, Windows 10 Professional; QTY: 1 iii. 30123658 - Monitor, Touchscreen, LCD, Planar; QTY: 1 iv. 30024944 - Keyboard and Mouse, Wireless; QTY: 1 v. CER - Virscidian Driver for HPLC control and analysis; QTY: 1 vi. CER - LCMS EVOware Driver; QTY: 1 vii. CER - SPT Labtech Receiver Driver; QTY: 1 k. Worktable Carriers i. 30097475 - DiTi Carrier , LiHa, 3-Position with Waste Site, includes DiTi Waste Chute and Cover, Silver; QTY: 1 ii. 30013061 - Microplate Carrier, 4-Position, Landscape, Low Profile; QTY: 6 iii. CER - MTP Tube Racks; QTY: 24 iv. CER - Flask locator under x rail; QTY: 1 v. CER - Mounting and access for SPT Labtech Receiver rear and left side; QTY: 2 2. 30001582 - Installation & Software Overview a. LW Labwerx In-house setup, testing, acceptance testing, installation 3. 30001572 - Shipping and Handling One (1) each of all products #1-3 listed in salient characteristics Anticipated period of performance: Product must have a 12-month manufacturer’s warranty to begin upon instrument installation. Delivery – Six months ARO. Other important considerations: Cite any other information that is necessary for potential respondents to understand the nature of the potential requirement or proposed acquisition. In case domestic sources are available and capable of fulfilling the Government’s need, and a future solicitation is published, the Government will use evaluation preferences in accordance with FAR 25. Capability statement /information sought. Small business concerns that believe they possess the capabilities to provide the required products should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Small businesses must also provide their Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. Interested small businesses are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. The respondent must also provide their Unique Entity ID from SAM.gov, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Michelle Cecilia, Contracting Officer at e-mail address michelle.cecilia@nih.gov and must include the Solicitation Number 75N95022Q00212. The response must be received on or before May 3, 2022, at 3:00 p.m., Eastern Time. “Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”