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COMBINED SYNOPSIS / SOLICITATION - COMPETITIVE Title: Compound library of 197 bioactive compounds: MedChemExpress (brand-name or equal) (i) This is a combined synopsis/solicitation for commercial item... COMBINED SYNOPSIS / SOLICITATION - COMPETITIVE Title: Compound library of 197 bioactive compounds: MedChemExpress (brand-name or equal) (i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii) The solicitation number is 75N95021Q00326 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures and FAR Part 12—Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. (iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2021-06, dated 06-10-2021. (iv) The associated NAICS code is 325414 and the small business size standard is 1,250 employees. This requirement is full and open with no set aside restrictions. (v) Through this procurement the Government intends to procure a compound library of 197 bioactive compounds as described in Attachment 1 – Purchase Description. NIDA anticipates the award of a Firm-Fixed Price (FFP) Purchase Order as a result of this solicitation. Below is the line item number and description of the requirement for the anticipated award. Line 1. FY21. Compound Library - 197 Bioactive Compounds. (vi) The National Center for Advancing Translational Sciences (NCATS) at the National Institues of Health (NIH) seeks to purchase a compound library of 197 bioactive compounds: MedChemExpress or brand-name equal. The specifications for the 197 compounds are identified in Attachment 1 – Purchase Description. The Government requires, brand-name or equal compound libraries that shall demonstarte the following salient characteristics: 1. Each compound must be provided in 5mg quantity. 2. Small molecules must have validated biological and pharmacological activities. 3. Each compound must be available for high-throughput screening (HTS) and high-content screening (HCS). 4. Each compound must come with detailed biological and chemical information with LC/MS and NMR reports to ensure high quality. 5. Each compound must be provided as a powder (solid). 6. Each compound must have a confirmed purity of >90% (accuracy +/-5%). 7. The compound library must conform to drug-like parameters such as distribution of molecular weight, solubility, lipophilicity, hydrogen bond donors and acceptors. 8. The compounds must be replenishable. They must be available for resupply or resynthesis if needed for NCATS follow up in the future. The Contractor must also provide the following information electronically for each individual compound. This information must be provided via email referencing individual compound vial barcodes: 1. Chemical structure or simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information 2. Supplier ID 3. Plate ID 4. Well location 5. Tube ID 6. Concentration in millimolar 7. Volume in microliters (vii) Delivery is to occur within ten (10) weeks after receipt of Government supplied tubes. Delivery shall be made to the below address with FOB Destination, to the point of contact designated on the purchase order. National Center for the Advancement of Translational Sciences 9800 Medical Center Drive, Room 315 Rockville, MD 20850 (viii) The provision at 52.212-1, Instructions to Offerors-Commercial, applies to this acquisition and a statement regarding any addenda to the provision. (ix) The provision at FAR clause 52.212-2, Evaluation – Commercial Items, applies to this acquisition. All offerors evaluated based on technical acceptability based on the Salient Characteristics described in Attachment 1. An award will be made to the offer that is the lowest evaluated price and meets or exceeds the acceptability standards for non-price factors. The non-price factors include the demonstrated technical capability to comply with the salient characteristics, as well as past performance. The Offeror must indicate in its quotation the ability to provide all of the specified products described above. The Offeror must indicate in its quotation the ability to meet the delivery requirements. Offerors price quote will be evaluated for reasonableness. For a price to be reasonable, it must represent a price to the government that a prudent person would pay when consideration is given to prices in the market. Normally, price reasonableness is established through adequate price competition, but may also be determined through cost and price analysis techniques. Price evaluation will not be conducted on any Offeror determined to be technically unacceptable. A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. (x) Offerors should include a completed copy of the provision at 52.212-3, Offeror Representations and Certifications-Commercial Items, with its offer. Offerors should include the representation at 52.204-24 if it is not in in their completed FAR Representations and Certifications. A copy of that representation is attached as Attachment 2 – Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment. Offerors should include the representation at 52.225-2 if it is not in in their completed FAR Representations and Certifications. A copy of that representation is attached as Attachment 4 – Representation Regarding 52.225-2 Buy American Certificate (FEB 2021). Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. Responses to this solicitation must include sufficient information to establish the interested parties’ bona-fide capabilities of performing the required service. Responses must also include the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), the certification of business size, and the completed offeror representation in FAR Provision 52.204-24, which is attached. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, product or catalog number(s); product description; what the warranty covers; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. All responsible sources may submit a quotation which shall be considered by the agency. (xi) The provision at FAR 52.212-4, Contract Terms and Conditions – Commercial Items, applies to this acquisition and is supplemented by Attachment 5 - 52.212-4 Addendum and (xii) The FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders—Commercial Items, applies to this acquisition and is supplemented by Attachment 6 - 52.212-5 Addendum. (xiii) In addition to the clauses checked in FAR 52.212-5 (attached), the following clauses also apply to this acquisition and are incorporated by reference: The clause at FAR 52.204-13, System for Award Management Maintenance (Oct 2018) The clause at FAR 52.204-18, Commercial and Government Entity Code Maintenance (Jul 2016) The clause at HHSAR 352.222-70, Contractor Cooperation in Equal Employement Opportunity Investigations (December 18, 2015) NIH Invoice and Payment Provisions (2/2014) included ast Attachment 3 – Invoice Instructions (xiv) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. (xv) All responses must be received by 1:00 p.m. EDT on August 31, 2021, and reference solicitation number 75N95021Q00326. Responses must be submitted via email to Shaun Rostad, Contract Specialist, at shaun.rostad@nih.gov. (xvi) For information regarding the solicitation, contact Shaun Rostad, Contract Specialist, at 301-443-6677 or shaun.rostad@nih.gov.

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DESCRIPTION The National Center for Advancing Translational Sciences (NCATS) and National Institutes of Health (NIH) is seeking Capability Statements from BOTH Other than Small Business and Small Busi... DESCRIPTION The National Center for Advancing Translational Sciences (NCATS) and National Institutes of Health (NIH) is seeking Capability Statements from BOTH Other than Small Business and Small Business organizations with the demonstrated capability of providing a pre-clinical screening library of small molecules. This is a Sources Sought Notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified business sources; (2) the availability of capable Small Businesses; HUBZone Small Businesses; Service-Disabled, Veteran-Owned Small Businesses; 8(a) Small Businesses; Veteran-Owned Small Businesses; Woman-Owned Small Businesses; or Small Disadvantaged Businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. The established NAICS code is 325414, Biological Product (except Diagnostic) Manufacturing. The U.S. Small Business Administration establishes a size standard for 325414 as 1,250 employees or less. BACKGROUND: The Early Translation Branch (ETB) of NCATS is looking to expand its pre-clinical screening library of small molecules. Adding diversity to chemical libraries is imperative to their operation, as they screen a variety of targets against these in-house collections. Screening is often the starting point in development and a wealth of knowledge is obtained from screening a diverse collection of molecules. It provides the starting point of all information for medicinal chemistry’s structure-activity relationship (SAR) design to synthesize novel compounds that have more desirable properties. A diverse and novel screening collection provides the backbone of our operation and is imperative for translational sciences to obtain effective small molecules with on-target effects. These small molecules have been designed around analysis of available chemical and biological information, identification of key pathways modules/targets, computational and “wet biology” assessment of target druggability and potential binding domains. The resulting information is analyzed by synthetic and medicinal chemistry teams to bring new chemical diversity and to design unique scaffolds that are likely to interact with the designated targets yielding focused compound libraries. Having such small molecules will make a huge impact in screening against the variety of targets that NCATS works on and will also help tremendously in bioinformatics analysis which will allow a more thorough and effective SAR expansion by the medicinal chemist. TECHNICAL REQUIREMENT: NCATS seeks to purchase one (1) chemical library of 195 compounds: MedChemExpress or brand-name equal. The specific 195 compounds are all part of MedChemExpress' Bioactive Compound Library and are identified in the attached list. Brand-name or equal compound libraries must have the following salient characteristics: 1. Each compound must be provided in 5mg quantity. 2. Small molecules must have validated biological and pharmacological activities. 3. Each compound must be available for high-throughput screening (HTS) and high-content screening (HCS). 4. Each compound must come with detailed biological and chemical information with LC/MS and NMR reports to ensure high quality. 5. Each compound must be provided as a powder (solid). 6. Each compound must have a confirmed purity of >90% (accuracy +/-5%). 7. The compound library must conform to drug-like parameters such as distribution of molecular weight, solubility, lipophilicity, hydrogen bond donors and acceptors. 8. The compounds must be replenishable. They must be available for resupply or resynthesis if needed for NCATS follow up in the future. The Contractor must also provide the following information electronically for each individual compound. This information must be provided via email referencing individual compound vial barcodes: Chemical structure or simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information Supplier ID Plate ID Well location Tube ID Concentration in millimolar Volume in microliters DELIVERY: Delivery must occur within ten weeks after receipt of Government supplied tubes. INSTRUCTIONS: All capability statements must also include the following: 1) company name and address; 2) point of contact; 3) phone/fax/email; 4) NAICS Code(s); 5) business size and status; 6) capability information in response to the requirement and qualifications identified in this notice; and 7) type of small business your organization classifies itself as (i.e.: Women-Owned, HUBZone, etc.). Any business concerns that believe they possess the capability necessary to successfully undertake the work described above must SUBMIT CAPABILITY STATEMENTS ELECTRONICALLY to the Contract Specialist, Shaun Rostad at Shaun.Rostad@nih.gov, NO LATER THAN 1:00 p.m. EST on Monday, July 29, 2021. The Subject line for the submission should include this Sources Sought Number. NIDA will not accept paper or faxed capability statements. THIS NOTICE IS NOT A REQUEST FOR PROPOSALS. This notice is for information and planning purposes only and does not commit the Government to any contractual agreement. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. CONFIDENTIALITY. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).