Inactive

NIH/CARD will generate long-read sequencing data from roughly 4000 patients with Alzheimer’s disease (AD), frontotemporal dementia (FTD), Lewy body dementia (LBD), and healthy subjects. This project w... NIH/CARD will generate long-read sequencing data from roughly 4000 patients with Alzheimer’s disease (AD), frontotemporal dementia (FTD), Lewy body dementia (LBD), and healthy subjects. This project will produce roughly 8000 terabytes of data, so the government will need a Contractor to develop pipelines for storing, analyzing, and harmonizing these large data sets on cloud-based computing platforms. The Contractor shall then use these datasets to identify DNA methylation changes and single nucleotide variants, both of which have been linked to normal aging and neurodegenerative diseases. The government will then use this service provided by the Contractor to evaluate how the epigenetic and genomic landscape in challenging regions contribute to the development of neurodegenerative diseases.