Inactive

SOLICITATION No. 75N95020Q00279 TITLE: In-vivo fluorescence microscope calcium imaging device This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Fe... SOLICITATION No. 75N95020Q00279 TITLE: In-vivo fluorescence microscope calcium imaging device This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotations are being requested and a separate written solicitation will not be issued. The solicitation number is 75N95020Q00279 and is issued as a Request for Quotation (RFQ). The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 2020-08, dated August 13, 2020. This acquisition is for a commercial item or service and is conducted under the authority of the FAR Part 13— Simplified Acquisition Procedures and FAR Part 12—Acquisition of Commercial Items and is not expected to exceed the simplified acquisition threshold. A fixed-price type of purchase order is contemplated for this requirement. The associated North American Industry Classification System (NAICS) code is 333314 (Optical Instrument and Lens Manufacturing) with associated small business size standard of 500 employees. This requirement is Brand Name or Equal, full and open competition. STATEMENT OF NEED AND PURPOSE: The purpose is to acquire a fluorescence microscope system that allows us to detect fluorescence signals indicating cellular calcium levels in rodents. This device enables us to observe how specific types of cell populations get activated during the mouse perform compulsive behavior. BACKGROUND INFORMATION: The Neurocircuitry of Motivation Section aims to understand neural circuits that mediate compulsive behaviors such as drug-taking and drug-seeking behaviors. We use rodent models to achieve this goal. Compulsive behaviors such as drug-seeking are generated by the interactions of many types of neurons in the brain. Historically, researchers used microelectrodes to detect the activity of single neurons. However, this method does not readily allow researchers to identify the types of neurons being recorded. The fluorescence microscope procedure is a state-of-art technology, which allows researchers to record unit activity of neurons in a cell-type- and region-specific manner by expressing fluofoures that respond to calcuim levels with viral technology. The fluorescence microscope calcium imaging technology helps researchers to understanding how selective populations of neurons are activated during compulsive behavior in rodents. PROJECT REQUIREMENT: The Contractor shall provide QTY one (1) Brand Name or Equal In-vivo fluorescence microscope calcium imaging device - Twist-on efocus Fluorescence Microscope System. The Brand Name or Equal In-vivo fluorescence microscope calcium imaging device - Twist-on efocus Fluorescence Microscope System shall meet all of the required salient characteristics/specifications: Salient Characteristics: The system must be able to detect fluorescent signals emitted by GCaMP7f expressed on the surface of individual neurons and record such signals at a mili-second resolution for a few hours at a time. The system must include both hardware and software to accomplish this task. The microscope component must be small and light in such a way that a mouse can wear it on its head and move about a chamber freely for a few hours at a time. STANDARD WARRANTY: The Contractor shall provide, at a minimum, a one-year warranty for the equipment. The warranty shall cover all parts, labor and travel costs. The warranty shall commence upon successful completion of delivery, installation and training. TRAINING: The Contractor shall provide two days of on-site training, at the above address, for up to four (4) personnel. Training must be conducted by a professional sales representative and completed immediately after delivery and installation. The training shall include, at a minimum, all equipment functions, equipment operation, troubleshooting and routine maintenance procedures. DELIVERY/INSTALLATION: The Contractor shall deliver and, as needed, install the instrument at the below address. Installation shall include, at a minimum, uncrating/unpacking of all equipment, set-up and hook-up of all equipment, start-up, demonstration of specifications and removal of all trash. The delivery date is 60 days after receipt of order (ARO). Delivery will be FOB Destination. The place of delivery and acceptance will be: National Institute on Drug Abuse 251 Bayview Blvd., Suite 200, BRC/Rm. 08A711 Baltimore, MD 21224 APPLICABLE PROVISIONS AND CLAUSES: The provision at FAR clause 52.204-24, Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (AUG 2020) is applicable to this solicitation. Offerors MUST include a completed copy of this provision with their offer, OR provide a copy of the valid certifications from the System of Award Management (SAM) applications at www.sam.gov, which may be indicated on the Offeror’s cover sheet. See attachment. The provision at FAR Clause 52.212-1, Instructions to Offerors-Commercial Items (JUN 2020) is applicable to this solicitation. The provision at FAR Clause 52.212-2, Evaluation-Commercial Items (OCT 2014) applies to this acquisition. The following is provided as an addendum to clause 52.212-2: (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, i.e. this RFQ will be evaluated on the basis of Lowest-Price Technically- Acceptable (LPTA). Offeror’s submitting a response must provide a completed Price Quote to be evaluated and considered for award. Price quotes must indicate fixed unit pricing and total costs, including shipping cost and estimated time of delivery after receipt of order. Under the LPTA process, Offeror’s will be determined to be “technically acceptable” or “technically unacceptable” based on an evaluation of responses against the following factors to determine if, as submitted, the proposal is technically acceptable. Award will be made to the lowest-priced, technically acceptable, responsible offeror. Technical acceptability shall be based on the following: The Offeror must indicate in its quotation the ability to provide all of the requirements. The Offeror must indicate in its quotation the ability to meet the delivery requirements. A written notice of award or acceptance of an offer mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer’s specified expiration time, the Government may accept an offer (or part of an offer), whether nor not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. Offerors may respond with a proposal indicating their ability to provide the technical specifications stated in this solicitation. Responses will be evaluated based on the contractor’s ability to meet the Government’s requirements. The provision at FAR Clause 52.212-3, Offeror Representations and Certifications—Commercial Items (JUN 2020), applies to this acquisition. Offerors MUST include a completed copy of the provision at 52.212-3, Offeror Representations and Certifications Commercial Items, with their offer, OR provide a copy of the valid certifications from the System of Award Management (SAM) applications at www.sam.gov, which may be indicated on the Offeror’s cover sheet. Addendum to FAR Clause 52.212-4, Contract Terms and Conditions-Commercial Items (OCT 2018), applies to this acquisition. The additional contract terms and conditions are as follows: 52.204-7 System for Award Management (OCT 2018) 52.204-13 System for Award Management Maintenance. (OCT 2018) 52.204-16 Commercial and Government Entity Code Reporting (JUL 2016) 52.204-18 Commercial and Government Entity Code Maintenance (JUL 2016) 52.242-15 Stop-Work Order (AUG 1989) The provision of FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items (AUG 2020), applies to this acquisition. See attachment. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Responses to this solicitation must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service. Responses to this solicitation must include clear and convincing evidence of the Offeror’s capability of fulfilling the requirement as it relates to the Government requirements stated in this solicitation. Cost and price information in the Offeror’s proposal must contain sufficient information to allow the Government to perform an analysis of the reasonableness of the Offeror to supply the required goods/services. Any other information or factors that may be considered in the award decision may include such factors as: past performance; special features required for effective service coverage; train-in considerations; warranty considerations; maintenance and service coverage availability; serial, product or catalog number(s); product description; delivery terms, and prompt payment discount terms. The Contractor shall submit its quote electronically. In addition, the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. DATE QUESTIONS DUE: Questions and requests for clarification must be submitted electronically to the Contracting Officer, Kenneth Goodling, at Kenneth.goodling@nih.gov and the Contract Specialist, Alexander Beraud, at alexander.beraud@nih.gov on or before 12:00 PM EST, September 21, 2020. Fax responses will NOT be accepted. DATE QUOTATIONS DUE: All responses must be received on September 23, 2020 by 11:00 AM EST and must be submitted electronically to the Contracting Officer, Kenneth Goodling, at Kenneth.goodling@nih.gov and the Contract Specialist, Alexander Beraud, at alexander.beraud@nih.gov,citing the RFQ number and the name of firm in the subject line. Late responses will NOT be accepted. Attachments: Attachment 1 – FAR 52.204-24, Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (AUG 2020) Attachment 2 – FAR Clause 52.212-4, Contract Terms and Conditions-Commercial Items (OCT 2018) Attachment 3 - FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (AUG 2020) Attachment 4 - Invoice and Payment Instructions

Inactive

Background This is a Small Business Sources Sought (SBSS) notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regar... Background This is a Small Business Sources Sought (SBSS) notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources? (2) whether they are small businesses? HUBZone small businesses? service disabled, veteran-owned small businesses? 8(a) small businesses? veteran-owned small businesses? woman-owned small businesses? or small disadvantaged businesses? and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability and type of qualified Small Business companies technically capable of meeting this potential government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. The notice is strictly for research and information purposes only. The information requested will assist the Government in determining the appropriate acquisition method including small business socioeconomic set aside possibilities and to determine the availability of qualified Small Business companies technically capable of meeting the Government's potential requirement. All Small Business companies with the capability and availability to perform the requirement under the applicable NAICS code are invited to submit a response to this notice. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 333314 - Optical Instrument and Lens Manufacturing Manufacturing with a Size Standard of 500 employees. DESCRIPTION OF REQUIREMENT Background The Neurocircuitry of Motivation Section aims to understand neural circuits that mediate compulsive behaviors such as drug-taking and drug-seeking behaviors. We use rodent models to achieve this goal. Compulsive behaviors such as drug-seeking are generated by the interactions of many types of neurons in the brain. Histologically, researchers used microelectrodes to detect the activity of single neurons. However, this method does not readily allow researchers to identify the types of neurons being recorded. The fluorescence microscope procedure is a state-of-art technology, which allows researchers to record unit activity of neurons in a cell-type- and region-specific manner by expressing fluorophores that respond to calcium levels with viral technology. The fluorescence microscope calcium imaging technology helps researchers to understanding how selective populations of neurons are activated during compulsive behavior in rodents. Purpose The purpose is to acquire a fluorescence microscope system that allows us to detect fluorescence signals indicating cellular calcium levels in rodents. This device enables us to observe how specific types of cell populations get activated during the mouse perform compulsive behavior. Project Requirements In-vivo fluorescence microscope calcium imaging devise - Twist-on efocus Fluorescence Microscope System Salient Characteristics The system must be able to detect fluorescent signals emitted by GCaMP7f expressed on the surface of individual neurons and record such signals at a millisecond resolution for a few hours at a time. The system must include both hardware and software to accomplish this task. The microscope component must be small and light in such a way that a mouse can wear it on its head and move about a chamber freely for a few hours at a time. CAPABILITY STATEMENT Interested parties are expected to review this notice to familiarize itself with the requirements of this product or service. Failure to do so will be at your firm's own risk. Respondents must provide, as part of their response: (a) product, catalog, model, and/or part number(s)? (b) product description? (c) best estimated delivery date after receipt of order? (d) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in this announcement. Respondents that believe that they are authorized resellers of the equipment described in this announcement may provide, in addition to the aforementioned information, as part of their response: quantity? estimated price or cost? shipping, handling, and/or installation charges. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11point or 12point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The information submitted must be in an outline format that addresses each of the elements of the product requirement. A cover page and an executive summary may be included but is not required. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and email addresses. Respondents must reference announcement number 75N95020Q00279 on all correspondence related to this Small Business Sources Sought notice. The response must be submitted electronically to alexander.beraud@nih.gov and kgoodlin@nida.nih.gov and be received prior to the closing date specified in this announcement. The response must be received on or before September 4, 2020, 11:00 am, Eastern Time. CONCLUDING STATEMENTS Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in beta.SAM. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any nonproprietary technical information in any resultant solicitation(s).