The National Cancer Institute (NCI) is seeking small business proposals to demonstrate technical feasibility and proof-of-concept for innovative technologies targeting pediatric and rare cancers, with a focus on those having a 5-year survival rate below 50%. Proposals must identify a clinical problem, cancer type, and development path, and include experiments for initial de-risking and proof-of-concept data. Awards will require enhancing entrepreneurial skills and developing a business model and commercialization plan. The solicitation is anticipated to be available around July 17, 2026, with a closing date in late September and an interim deadline in June for white paper submissions. No budget amounts or performance location are specified.