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Title: Procurement of a brand name or equal Closed Nebulizer System Document Type: Combined Synopsis / Solicitation Notice Solicitation Number: 75N91021Q00120 Proposed Posted Date: 6/22/2021 Proposed ... Title: Procurement of a brand name or equal Closed Nebulizer System Document Type: Combined Synopsis / Solicitation Notice Solicitation Number: 75N91021Q00120 Proposed Posted Date: 6/22/2021 Proposed Response Date: 7/6/2021 Classification Code: 66 – Instruments and laboratory equipment NAICS Code: 334516 – Analytical Laboratory Instrument Manufacturing Business Size Standard: 1000 Employees Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E122, Bethesda, MD 20892, UNITED STATES. Description of Requirement The National Cancer Institute (NCI), Center for Cancer Research (CCR), would like to procure a Brand Name or Equal Closed Nebulizer System. This is a combined synopsis/solicitation for commercial items, prepared in accordance with format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation: No. 75N91021Q00120 includes all applicable provisions and clauses in effect through FAR FAC 2021-05 (MAR 2021) simplified procedures for commercial items. The North American Industry Classification System code is 334516 and the business size standard is 1000 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. 1.0 BRAND NAME OR EQUAL This requirement is for the procurement of the brand name or equivalent instruments described in section 4.0. The Federal Acquisition Regulation (FAR) provision FAR 52.211-6, Brand Name or Equal (AUG 1999) is applicable to this requirement. BACKGROUND The Thoracic Surgery Branch (TSB) primary research interest is in understanding the cause of lung cancer via smoking. Lung cancer is the leading cause of cancer-related deaths worldwide. The TSB branch would like to test epigenetic agents by using aerosolization techniques that appear to enhance drug delivery to pulmonary malignancies while markedly decreasing systemic toxicities. Recently we developed an immunocompetent mouse pulmonary metastasis model using stem cells isolated and expanded from syngeneic cancers. The requested nebulizer inhalation system will be used to perform preclinical experiments to evaluate toxicities and potential therapeutic efficacy of epigenetic agents which will be administered by aerosolization techniques alone or in combination with immunotherapeutic agents as a strategy to target cancer stem cells in pulmonary malignancies. TYPE OF ORDER This will be issued as a Firm Fixed-Price Purchase Order. SPECIAL ORDER REQUIREMENTS PRODUCT FEATURES/SALIENT CHARACTERISTICS The following product features/characteristics are required for this requirement: The exposure part of the system needs to be equipped with appropriate animal restrainers to expose mice. The nose-only chamber needs be operated under positive pressure. The system should have the ability to control the concentration of the test atmosphere in the chamber by mixing the aerosol coming from the aerosol generator with accurately controlled amounts of clean dilution air. The system should include a control unit specifically designed for open positive pressure systems. Chamber exhaust is freely vented inside the ventilated enclosure. The system should be designed with a Blaustein Atomizing Modules (BLAM) nebulizer for generating aerosols from liquid solutions or suspensions. The system should include a light scattering aerosol concentration monitor, an impactor, and a gravimetric sampler, which can provide the necessary measurements to characterize the exposure to test article aerosols in use. The system also needs to have a pump to provide external liquid feed for the nebulizers when they are used in single pass mode DELIVERY / INSTALLATION The closed nebulizer system shall be delivered to the Contracting Officer Representative (COR), within 30 days of purchase order award to Bethesda, MD 20892. The Contractor that receives the award will be provided with the complete mailing address and point of contact. Upon award, contractor must notify the NCI COR to schedule the delivery. A minimum 12-month manufacturer warranty must be included Shipping/Handling costs must be included in the quote. NCI will not be responsible in the event charges are not included in the quote. Installation charges must be included in the quote. Note: NCI plans to award a contract that has FOB origin delivery terms. 4.3 TRAINING Per Diem - On-site installation, system set-up, and training by systems engineer. 45 day advance notice required for travel plans 4.4 WARRANTY The Contractor shall warrant that any instruments, equipment, components, or other supplies (“Supplies”) procured by this purchase are free of defects in design, material, or manufacture for a period of at least one (1) calendar year from date of acceptance by the Government. The Contractor shall warrant that all consumables or expendable parts are free of defects in design, material or manufacture for a period of at least 90 calendar days from date of acceptance by the Government. Supplies which are repaired or replaced shall be warranted for the remainder of the initial warranty period or for 90-days – whichever is greater.