Inactive

The Centers for Disease Control and Prevention intends to award a sole source firm fixed price purchase order to The Washington University for identifying metabolomic features shared by in vitro and i... The Centers for Disease Control and Prevention intends to award a sole source firm fixed price purchase order to The Washington University for identifying metabolomic features shared by in vitro and in vivo human intestinal microbiome disruption. The intended contractor houses a research and development group that has honed years of experience in a highly specific and technical area. To accomplish the tasks as written in the SOW, a strong inter-disciplinary group is required for analysis of experimental and clinical data along with a unique combination of expertise in microbiology, bioinformatics, and ecological modeling. In addition, the principal lead scientist has 10+ years of experience running such experimental and theoretical systems. Thus, these knowledge, skills, and abilities will be used to create a product which does not exist and has no comparable platform available in the open market. This work will build on the current prototype system that tracks multiple metabolite biomarkers of disruption in a static vial reactor system (SVRS) culture. The objective of this project is to validate these biomarkers by monitoring them in human subjects with and without antibiotic-mediated disruption. This work will yield a SVRS protocol that is demonstrably relevant to in vivo intestinal microbiome function in humans.. This contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under the authority of FAR 6.302-1 and 41 U.S.C. 3304(a)(1). Interested persons may identify their interest and capability to respond to the requirement or submit proposals. This notice of intent is not a request for competitive quotations; however, all quotations/responses received within fifteen (15) days of the issuance of this notice will be considered by the government. A determination by the government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Any quotation/response should be emailed to Kurt Schaal at AWR3@cdc.gov by July 29, 2022 at 2:00 P.M. EST.