Argonne National Laboratory is seeking input on opportunities to participate in developing a National Genesis Mission Supercomputing Center of Innovation, which will include AI supercomputing resources located on Argonne property. The center aims to strengthen U.S. leadership in AI and accelerate scientific discovery through public-private collaboration. Argonne is evaluating approaches for computing infrastructure and partnership models, with an emphasis on substantial private-sector investment to finance most infrastructure. The RFI is for information-gathering only and does not constitute a solicitation or commitment to any award. No specific timelines, budget amounts, or performance location beyond Argonne property are mentioned.