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Centrifugation is a technique that helps to separate mixtures by applying centrifugal force. A centrifuge is a device, generally driven by an electric motor that puts an object (i.e., a rotor) in a ro... Centrifugation is a technique that helps to separate mixtures by applying centrifugal force. A centrifuge is a device, generally driven by an electric motor that puts an object (i.e., a rotor) in a rotational movement around a fixed axis. A centrifuge works by using the principle of sedimentation: under the influence of gravitational force (g-force), substances separate according to their density.