This is a Request for Information (RFI) only for planning purposes and is not a solicitation for proposals. The Air Force Research Laboratory seeks information on contractor capabilities to conduct research and development in three main areas: Novel Laser Bioeffects, Nuclear Flash and Laser Eye Protection, and Directed Energy Modeling, Simulation, and Analysis. The work involves basic to applied research to understand biological effects, develop protective systems, and create modeling tools related to directed energy technologies. No specific budget, performance location, or response timeline for a future solicitation is provided in this RFI description.