DARPA is seeking innovative approaches to create continuously updating digital twin models of the cardiovascular system, which would simulate interventions in real time to predict outcomes before actual patient procedures. The VITAL program aims to establish a foundation for predictive, causal decision support in medicine. This capability is intended to shift medical care from reactive to anticipatory, potentially improving outcomes in acute, chronic, and emergent clinical settings. No specific budget, performance location, or non-bid/proposal timelines are detailed in this description.