DARPA is seeking innovative proposals to eliminate invasive species like the New World Screwworm and Brown Tree Snake in Guam using genetic drive technologies. The program includes three technical areas: one for eradicating the Brown Tree Snake with an 18-month lab testing phase and an 18-month contained testing phase, one for developing accelerated cell culture methods, and one for population modeling. The work for the Brown Tree Snake eradication is specifically intended for performance in Guam. The proposal must emphasize genetic precision, built-in control measures, and meeting regulatory requirements for future field trials. This amendment clarifies submission instructions and abstract content.

DARPA is seeking innovative proposals to eliminate invasive species like the New World Screwworm and Brown Tree Snake in Guam using genetic drive technologies. The GUARDIAN program has three technical areas: one for eradicating the Brown Tree Snake through 18-month phases of modeling, lab testing, and contained testing; another to develop accelerated cell culture methods; and a third for population modeling. The work for the snake eradication involves a structured 18-month Phase 1 and an 18-month Phase 2. The performance location for the Brown Tree Snake work is specified as Guam. The program emphasizes genetic precision, control safeguards, and meeting regulatory requirements for future field trials.