DARPA anticipates soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. The capability’s utility will be demonstrated by identifying novel diagnostic and therapeutic targets within the interaction space underlying conditions including traumatic brain injury. This is a presolicitation notice for information only; the official solicitation will be issued later, and all information is draft and subject to change. The published Program Announcement on SAM.gov will take precedence in case of conflict.