Inactive

Target: Synthesis of Targets Structure of Targets Deliverables Target: Total 16 samples; 10~20 mg each Purity: ? 95 % LC-MS, HPLC, and NMR Compounds delivered on regular intervals Cost Estimate per co... Target: Synthesis of Targets Structure of Targets Deliverables Target: Total 16 samples; 10~20 mg each Purity: ? 95 % LC-MS, HPLC, and NMR Compounds delivered on regular intervals Cost Estimate per compound Estimated Timeline: Timeline: ~ 12-14 weeks Notes: The price includes all the purification/analytical cost, common reagents, general consumables, and QC. Timeline is an estimate. Proposed synthetic routes Key Intermediate Synthesis Notes: Ref) Journal of Medicinal Chemistry, 58(1), 401-418; 2015 Target-1, 2, and 3 Notes: Two steps synthesis from 2: Choice of protecting group for 2: Ac will be tried first. Boc PG for will be an alternative. In final step, the Ac group will be installed after deprotection of Boc Targets 4 - 8 Synthesis of Key Heterocycles Notes: Vinyl pyrazine 6 (Cas# 620596-94-3): Two step from 5; Suzuki, followed by de-Boc Epoxy pyrazine 7: Three steps from 5 (P=Boc). Requires chemistry validation for epoxidation. Chloro vinyl pyrazine 8: Two steps from 5 (P=Boc). Requires chemistry validation Chloromethyl amino pyrazine 10 For Target-7: Two steps from 9. Requires chemistry validation Completion of the Synthesis of targets 4 to 8 Notes: Two steps synthesis from 2 If epoxide 7 poses any issues during the synthesis of Target 6 we will use target 5 and perform epoxidation to generate the final target compound Targets 9-11 Notes: Target-9 and -10: 4 steps synthesis from 11: Requires chemistry validation for urea/thiourea formation Target-11: One step synthesis from 11 Target-12 Notes: Four steps synthesis is proposed: Requires chemistry validation Target-13~16 Notes: Key Intermediate 16: To be synthesized by the reaction of 4 with racemic 3-hydroxypyrrolidine Target-13: Mitsunobu condition would be the first choice then hydrolysis Target14: Mitsunobu condition would be first choice Target-15: Ether formation by substitution: Methyl ester of 19 would be required. Target-16: key intermediate 16 to be reacted with chloro (X= Cl) compound (20, to be synthesized from X= OH) under NaH/THF.